N-[(E)-4,10-dimethoxy-5,9-dimethyl-6-oxo-11-[(5E,7E,13E,19E)-3,15,17,21,23-pentamethoxy-5,12,18,24-tetramethyl-9,27-dioxo-10,26-dioxabicyclo[23.3.1]nonacosa-1(28),5,7,13,19-pentaen-11-yl]dodec-1-enyl]-N-methylformamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: N-[(E)-4,10-dimethoxy-5,9-dimethyl-6-oxo-11-[(5E,7E,13E,19E)-3,15,17,21,23-pentamethoxy-5,12,18,24-tetramethyl-9,27-dioxo-10,26-dioxabicyclo[23.3.1]nonacosa-1(28),5,7,13,19-pentaen-11-yl]dodec-1-enyl]-N-methylformamide
• 化学式: C₅₄H₈₇NO₁₃
• 分子量: 958.3
• InChiKey: LOYDTENNTZZQJM-UXZQNECESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  68
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  155
• 氢给体数：
  0
• 氢受体数：
  13

文献信息

• Zika virus protease inhibitors and methods of use thereof
  申请人：VERSITECH LIMITED

  公开号：US11517581B2

  公开（公告）日：2022-12-06

  Methods and compounds for preventing and/or treating Zika virus (ZIKA) infection. And methods to screen for compound to prevent or treat Zika virus infection.

  预防和/或治疗寨卡病毒（ZIKA）感染的方法和化合物。以及筛选预防或治疗寨卡病毒感染的化合物的方法。
• COMPOSITIONS AND METHODS FOR GLAUCOMA
  申请人：Aufbau Medical Innovations Limited

  公开号：EP3852608A1

  公开（公告）日：2021-07-28
• Macrolide analogs and methods for identifying same
  申请人：——

  公开号：US20040259185A1

  公开（公告）日：2004-12-23

  Macrolide analogs and methods for identifying macrolide analogs capable of unregulated inhibition of actin filament dynamics are provided. A method according to the invention includes the steps of: (a) contacting F-actin with a candidate compound; and (b) assaying the candidate compound's ability to sever the F-actin and cap resulting F-actin (+)-ends. The candidate compound is identified as a macrolide analog where said candidate compound displays an ability to sever F-actin and, following severing, the resulting F-actin (+)-end is capped by the candidate compound thusly preventing subsequent G-actin incorporation. Severing and capping activities are unregulated; i.e., independent of at least physiologically-meaningful concentrations of phosphatidyl inositol and calcium.
• REGULATED BIOCIRCUIT SYSTEMS
  申请人：Obsidian Therapeutics, Inc.

  公开号：US20190192691A1

  公开（公告）日：2019-06-27

  The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
• ZIKA VIRUS PROTEASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：VERSITECH LIMITED

  公开号：US20200384005A1

  公开（公告）日：2020-12-10

  Methods and compounds for preventing and/or treating Zika virus(ZIKA) infection. And methods to screen for compound to prevent or treat Zika virus infection.