(5Z)-3-(piperidin-1-ylmethyl)-5-[(4-propan-2-ylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (5Z)-3-(piperidin-1-ylmethyl)-5-[(4-propan-2-ylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C₁₉H₂₄N₂OS₂
• 分子量: 360.5
• InChiKey: BSYFJKQUWXSFDJ-ATVHPVEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  80.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Low molecular weight Myc-Max inhibitors
  申请人：Metallo J. Steven

  公开号：US20070203188A1

  公开（公告）日：2007-08-30

  Compounds and compositions for interfering with the association of Myc and Max are described herein. These compounds and compositions are useful in methods inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell are provided, comprising contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell.

  本文描述了干扰Myc和Max结合的化合物和组合物。这些化合物和组合物在抑制细胞生长或增殖的方法中很有用。本文提供了抑制细胞生长或增殖的方法，包括接触细胞与干扰Myc和Max结合的化合物的有效量，以抑制细胞生长或增殖。
• COMBINATION METHODS FOR TREATMENT OF DISEASE
  申请人：Rahl Peter B.

  公开号：US20130053415A1

  公开（公告）日：2013-02-28

  In some aspects, the invention provides compositions and methods of use for treating a variety of diseases. In some aspect, the compositions and methods involve combined modulation of transcriptional modulators.
• SUPER-ENHANCERS AND METHODS OF USE THEREOF
  申请人：Whitehead Institute for Biomedical Research

  公开号：US20140296218A1

  公开（公告）日：2014-10-02

  The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer).
• US7872027B2
  申请人：——

  公开号：US7872027B2

  公开（公告）日：2011-01-18
• US9155724B2
  申请人：——

  公开号：US9155724B2

  公开（公告）日：2015-10-13