Dichloro-P-cymene | 81686-46-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Dichloro-P-cymene
• 英文别名: 1,3-dichloro-2-methyl-5-propan-2-ylbenzene
• CAS: 81686-46-6；65724-12-1
• 化学式: C₁₀H₁₂Cl₂
• 分子量: 203.1
• InChiKey: FWCVXUYEZQQEGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• [EN] SUBSTITUTED GEMCITABINE ARYL AMIDE ANALOGS<br/>[FR] ANALOGUES ARYLAMIDES SUBSTITUÉS DE GEMCITABINE
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2014074725A1

  公开（公告）日：2014-05-15

  In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating viral disorders and disorders of uncontrolled cellular proliferation using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，该发明涉及替代的吉西他滨芳基酰胺类似物，其衍生物和相关化合物；合成制备这些化合物的方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗病毒性疾病和细胞不受控制增殖的疾病的方法。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。
• Methods and compositions of novel triazine compounds
  申请人：Timmer T. Richard

  公开号：US20070117795A1

  公开（公告）日：2007-05-24

  The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

  本发明涉及治疗由炎症反应引起的病理生理状况的方法和组合物。特别是，本发明涉及抑制或阻断糖基化蛋白质诱导内皮细胞信号相关炎症反应的化合物。本发明涉及抑制平滑肌增殖的化合物。特别是，本发明涉及通过调节HSPGs（如Perlecan）抑制平滑肌细胞增殖的化合物。本发明进一步涉及使用化合物治疗以平滑肌增殖为特征的血管闭塞性疾病，如再狭窄和动脉粥样硬化。
• SUBSTITUTED GEMCITABINE ARYL AMIDE ANALOGS
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：US20150259375A1

  公开（公告）日：2015-09-17

  In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating viral disorders and disorders of uncontrolled cellular proliferation using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  这项发明涉及替代gemcitabine芳基酰胺类似物、其衍生物和相关化合物；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗病毒性疾病和细胞不受控制增殖的疾病的方法。本摘要旨在作为搜索特定领域的工具，不限制本发明。
• FUSED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION
  申请人：Norris Derek J.

  公开号：US20100331324A1

  公开（公告）日：2010-12-30

  Disclosed are fused heterocyclic compounds of Formula (I) or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at least one androgen receptor-associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.

  本发明公开了式（I）的融合杂环化合物或其药学上可接受的盐或立体异构体。本发明还公开了使用这种化合物治疗至少一种雄激素受体相关疾病的方法，例如癌症，并且还公开了包含这种化合物的制药组合物。
• Process for producing 2,5-dichlorotoluene
  申请人：KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0257866B1

  公开（公告）日：1990-03-07