[(1S,7S,8S,8aS)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-6-oxo-2,7,8,8a-tetrahydro-1H-naphthalen-1-yl] 2,2-dimethylbutanoate | 130468-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: [(1S,7S,8S,8aS)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-6-oxo-2,7,8,8a-tetrahydro-1H-naphthalen-1-yl] 2,2-dimethylbutanoate
• CAS: 130468-11-0
• 化学式: C₂₅H₃₆O₆
• 分子量: 432.5
• InChiKey: NPDFVGFXQSJBAA-CKLJVHAJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Combination of an aldosterone receptor antagonist and an HMG CoA reductase inhibitor
  申请人：Keller T. Bradley

  公开号：US20060003975A1

  公开（公告）日：2006-01-05

  Novel methods and combinations for the treatment and/or prophylaxis of a pathologic condition in a subject, wherein the methods comprise the administration of one or more HMG Co-A reductase inhibitors and one or more aldosterone receptor antagonists, and the combinations comprise one or more HMG Co-A reductase inhibitors and one or more of said aldosterone receptor antagonists.

  用于治疗和/或预防受试者病理状况的新方法和组合，其中所述方法包括施用一种或多种 HMG Co-A 还原酶抑制剂和一种或多种醛固酮受体拮抗剂，所述组合包括一种或多种 HMG Co-A 还原酶抑制剂和一种或多种所述醛固酮受体拮抗剂。
• COMBINATION THERAPY EMPLOYING ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS
  申请人：G.D. SEARLE & CO.

  公开号：EP0971744A2

  公开（公告）日：2000-01-19
• COMBINATION OF AN ALDOSTERONE RECEPTOR ANTAGONIST AND AN HMG COA REDUCTASE INHIBITOR
  申请人：Pharmacia Corporation

  公开号：EP1406660B1

  公开（公告）日：2007-06-06
• US6264938B1
  申请人：——

  公开号：US6264938B1

  公开（公告）日：2001-07-24
• [EN] COMBINATION THERAPY EMPLOYING ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS<br/>[FR] TRAITEMENT ASSOCIE UTILISANT DES BENZOTHIEPINES INHIBITRICES DU TRANSPORT ILEAL DE L'ACIDE BILIAIRE ET DES INHIBITEURS DE LA HMG Co-A REDUCTASE
  申请人：——

  公开号：WO1998040375A2

  公开（公告）日：1998-09-17

  [EN] Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.
  [FR] La présente invention concerne des benzothiépines, certains de leurs dérivés et de leurs analogues. L'invention concerne également des compositions contenant ces benzothiépines, dérivés et analogues. L'invention concerne enfin des procédés permettant d'utiliser ces composés et compositions dans des médicaments, en particulier pour la prophylaxie et le traitement d'états hyperlipidémiques tels que ceux qui sont liés chez les mammifères à l'athérosclérose ou l'hypercholestérolémie. L'invention concerne en outre des compositions et des procédés applicables dans un traitement associé utilisant des benzothiépines inhibitrices du transport iléal de l'acide biliaire et des inhibiteurs de la HMG Co-A réductase pour le traitement d'états hyperlipidémique.