3-(3,4-dichlorophenyl)-2-(dimethylamino)-2-methylpropan-1-ol;hydron;chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3,4-dichlorophenyl)-2-(dimethylamino)-2-methylpropan-1-ol;hydron;chloride
• 化学式: C12H18Cl3NO
• 分子量: 298.6
• InChiKey: NNDDTMNURXAVLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.27
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  23.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (S)-(-)-2-amino-2(3,4-dichlorobenzyl)-1-propanol 以84的产率得到3-(3,4-dichlorophenyl)-2-(dimethylamino)-2-methylpropan-1-ol;hydron;chloride
  参考文献：
  名称：

  Aminoalcohols, their preparation process and their applications,

  摘要：

  式子为：##STR1##的氨基醇，其中R.sub.1是烷基，R.sub.2是氢或烷基，R.sub.3特别是氢，烷基，苯基烷基，脂肪酰基，苯基脂肪酰基，其中N，R.sub.2和R.sub.3共同形成一个由5到7个链链接饱和的杂环。用于镇痛的药物。

  公开号：

  US04994617A1

文献信息

• Aminoalcohols, their preparation process and their applications,
  申请人：Jouveinal S.A.

  公开号：US04994617A1

  公开（公告）日：1991-02-19

  Aminoalcohols of formula: ##STR1## in which R.sub.1 is alkyl, R.sub.2 H or alkyl, R.sub.3 in particularly H, alkyl, phenylakyl, alkanoyl, phenylalkanoyl, in which N, R.sub.2 and R.sub.3 together form a heterocycle saturated with 5 to 7 chain links. Analgesic medicaments.

  式子为：##STR1##的氨基醇，其中R.sub.1是烷基，R.sub.2是氢或烷基，R.sub.3特别是氢，烷基，苯基烷基，脂肪酰基，苯基脂肪酰基，其中N，R.sub.2和R.sub.3共同形成一个由5到7个链链接饱和的杂环。用于镇痛的药物。
• Use of combinations comprising a corticosteroid and a pyrimidopyrimidine in the treatment of inflammatory diseases
  申请人：Combinatorx, Incorporated

  公开号：EP2070550A1

  公开（公告）日：2009-06-17

  The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.

  本发明的特点是通过向患者单独或与一种或多种附加制剂联合使用四取代嘧啶嘧啶，治疗被诊断患有或有可能患上免疫炎症性疾病的患者。本发明的另一个特点是含有四取代嘧啶嘧啶的组合物与一种或多种附加制剂的组合物。
• Methods, compositions, and kits for the treatment of ophthalmic disorders
  申请人：CombinatoRx, Inc.

  公开号：EP2218442A1

  公开（公告）日：2010-08-18

  The invention features methods, compositions and kits comprising a corticosteroid and a non-steroidal immunophilin-dependent immunosuppressant for treating an ophthalmic disorder in a patient, wherein at least one of said corticosteroid and said non-steroidal immunophilin-dependent immunosuppressant is present at a low concentration, in particular wherein said corticosteroid is prednisolone acetate and said non-steroidal immunophilin-dependent immunosuppressant is cyclosporine A.

  本发明的特征是包含皮质类固醇和非类固醇免疫嗜血素依赖性免疫抑制剂的方法、组合物和试剂盒，用于治疗患者的眼科疾病、其中，所述皮质类固醇和所述非类固醇免疫嗜血素依赖性免疫抑制剂中至少有一种以低浓度存在，特别是所述皮质类固醇为醋酸泼尼松龙，所述非类固醇免疫嗜血素依赖性免疫抑制剂为环孢素 A。
• Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
  申请人：——

  公开号：US20040229849A1

  公开（公告）日：2004-11-18

  The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.

  本发明的特点是通过向患者施用 SSRI 或其类似物或代谢物以及皮质类固醇或其他化合物来治疗被诊断患有或有可能患上免疫炎症性疾病的患者。本发明的另一个特点是含有 SSRI 或其类似物或代谢物和皮质类固醇或其他化合物的药物组合物，用于治疗或预防免疫炎症性疾病。
• Combination therapy for the treatment of immunoinflammatory disorders
  申请人：——

  公开号：US20040224876A1

  公开（公告）日：2004-11-11

  The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a non-steroidal immunophilin-dependent immunosuppressant (NsIDI) and an NsIDI enhancer (NsIDIE) or analog or metabolite thereof to the patient. The invention also features a pharmaceutical composition containing an NsIDI and NsIDIE or analog or metabolite thereof for the treatment or prevention of an immunoinflammatory disorder.

  本发明的特点是通过向患者施用非甾体类免疫嗜血素依赖性免疫抑制剂（NsIDI）和NsIDI增强剂（NsIDIE）或其类似物或代谢物来治疗被诊断患有或有可能患上免疫炎症性疾病的患者。本发明还具有一种含有 NsIDI 和 NsIDIE 或其类似物或代谢物的药物组合物，用于治疗或预防免疫炎症性疾病。