[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,2R,4aS,6aS,6aS,6bR,10S,11S,12aR,14bR)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate | 88515-58-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,2R,4aS,6aS,6aS,6bR,10S,11S,12aR,14bR)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
• CAS: 88515-58-6
• 化学式: C₃₆H₅₈O₁₀
• 分子量: 650.8
• InChiKey: MLKQAGPAYHTNQQ-ZFCIFJTHSA-N

物化性质

• 熔点：
  214-216 °C
• 沸点：
  741.5±60.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)
• 溶解度：
  溶于二甲基亚砜

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  46
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  177
• 氢给体数：
  7
• 氢受体数：
  10

制备方法与用途

生物活性

Rosamultin 是一种从 Potentilla anserina L. 分离出的 19 α-羟基熊果烷型三萜，能够抑制 HIV-1 蛋白酶。研究表明，Rosamultin 对 H2O2 诱导的氧化损伤和细胞凋亡具有保护作用。

靶点

Target	Value
HIV-1 protease	()

体外研究

从金蔷薇根部提取的 Rosamultin 在浓度为 100 μM 的情况下，能够抑制 HIV-1 蛋白酶活性 53%。

化学性质

Rosamultin 是一种白色结晶粉末，可溶于甲醇、乙醇和 DMSO 等有机溶剂。它来源于金樱根。

用途

野蔷薇苷具有抗氧化和抑菌的作用。

文献信息

• POLYHYDROXYLATED PENTACYCLIC TRITERPENE ACIDS AS HMG-COA REDUCTASE INHIBITORS
  申请人：Hans, Joachim

  公开号：EP2812005A1

  公开（公告）日：2014-12-17
• [EN] SWEETENER, SWEETENER COMPOSITIONS, METHODS OF MAKING THE SAME AND CONSUMABLES CONTAINING THE SAME<br/>[FR] ÉDULCORANT, COMPOSITIONS D'ÉDULCORANT, LEURS PROCÉDÉS DE FABRICATION ET PRODUITS COMESTIBLES EN CONTENANT
  申请人：NUTRINOVA GMBH

  公开号：WO2012107202A1

  公开（公告）日：2012-08-16

  The present invention relates to the use of tormentic acid or a derivative or a stereoisomer, or a salt or a hydrate thereof as a sweetener, to sweetener compositions comprising tormentic acid or a derivative or a stereoisomer, or a salt or a hydrate thereof, and, optionally, a pregelatinized starch, to methods of making the sweetener compositions and to tabletop sweetener compositions comprising tormentic acid or a derivative or a stereoisomer, or a salt or a hydrate thereof. Further, the invention relates to consumables comprising a consumable product and tormentic acid or a derivative or a stereoisomer, or a salt or a hydrate thereof. Preferred consumable products are water-based consumables, solid dry consumables, dairy products, dairy-derived products and dairy-alternative products.
• [EN] POLYHYDROXYLATED PENTACYCLIC TRITERPENE ACIDS AS HMG-COA REDUCTASE INHIBITORS<br/>[FR] ACIDES TRITERPÈNES PENTACYLIQUES POLYHYDROXYLÉS EN TANT QU'INHIBITEURS D'HMG-COA RÉDUCTASE
  申请人：HANS JOACHIM

  公开号：WO2013171100A1

  公开（公告）日：2013-11-21

  The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-Co A reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-Co A reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.