(1R,3R,9R,10S,13S,16S,17R)-8-tert-butyl-6,9,12,17-tetrahydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R,3R,9R,10S,13S,16S,17R)-8-tert-butyl-6,9,12,17-tetrahydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione
• 化学式: C₂₀H₂₄O₁₁
• 分子量: 440.4
• InChiKey: AMOGMTLMADGEOQ-WYRVYBOWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  169
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• USE OF PESTICIDAL ACTIVE CARBOXAMIDE DERIVATIVE IN SOIL AND SEED APPLICATION AND TREATMENT METH-ODS
  申请人：BASF Agrochemical Products B.V.

  公开号：EP3456201A1

  公开（公告）日：2019-03-20

  The present invention relates to agricultural methods and the use of an insecticidal active carboxamide derivative in seed treatment and soil application methods. The insecticidal carboxamide derivative is highly suitable alone or in combination with other active agricultural ingredients for controlling animal pests such as insects and/or spider mites and/or nematodes by treating the soil/growth substrate by drenching or drip application or dipping or soil injection.

  本发明涉及农业方法和杀虫活性羧酰胺衍生物在种子处理和土壤施用方法中的用途。 杀虫活性羧酰胺衍生物非常适合单独使用或与其他活性农用成分结合使用，通过淋施、滴施、浸渍或土壤注射处理土壤/生长基质，控制动物害虫，如昆虫和/或蜘蛛螨和/或线虫。
• EXTRACT OF GINKGO BILOBA LEAVES AND PREPARATION METHOD THEREFOR
  申请人：SPH Xing Ling Sci. & Tech. Pharmaceutical Co., Ltd.

  公开号：EP3842053A1

  公开（公告）日：2021-06-30

  Provided is an extract of Ginkgo biloba leaves as a crude drug, prepared by alcohol extraction of Ginkgo biloba leaves, comprising ≤4.0% of rutin, ≤0.4% of quercetin, 2.6-4.8% of bilobalide, 0.1-0.5% of ginkgolide J, ≤0.5% of residual ethanol, and ≤ 0.02% of biflavones, the biflavones comprising amentoflavone, bilobetin, and ginkgetin. The extract does not comprise genistin and ginkgolide M. Also provided is a method for preparing the extract of Ginkgo biloba leaves as a crude drug, comprising: extracting minced Ginkgo biloba leaves with an aqueous ethanol solution by heating under reflux, followed by filtration to obtain a filtrate; subjecting the filtrate to concentration followed by precipitation in water to obtain a supernatant, which is then centrifuged to obtain a centrifugate; loading the centrifugate to a macroporous resin column and conducting water washing and solvent elution to obtain a first eluate, then loading a low concentration solvent first eluate to a polyamide column and conducting water washing and ethanol elution to obtain a second eluate; combining the second eluate with a high concentration solvent first eluate and conducting concentration, followed by extraction, drying, milling, sieving, and blending. The resulting extract of Ginkgo biloba leaves as a crude drug can be prepared into various formulations containing the extract.

  本发明提供了一种银杏叶提取物粗药，由银杏叶醇提制备而成，其中芦丁含量≤4.0%，槲皮素含量≤0.4%，双叶皂甙含量2.6-4.8%，银杏内酯J含量0.1-0.5%，残留乙醇含量≤0.5%，双黄酮含量≤0.02%，双黄酮包括门冬酰胺黄酮、双叶黄素和银杏黄素。提取物中不包括染料木苷和银杏内酯 M。还提供了一种制备银杏叶提取物粗药的方法，包括用乙醇水溶液在回流下加热提取碎银杏叶，然后过滤，得到滤液； 将滤液浓缩，然后在水中沉淀，得到上清液，然后离心，得到离心物；将离心液装入大孔树脂柱，进行水洗和溶剂洗脱，得到第一洗脱液，然后将低浓度溶剂第一洗脱液装入聚酰胺柱，进行水洗和乙醇洗脱，得到第二洗脱液；将第二洗脱液与高浓度溶剂第一洗脱液混合，进行浓缩，然后进行提取、干燥、研磨、筛分和混合。由此得到的银杏叶提取物作为一种粗制药物，可配制成各种含有该提取物的制剂。
• GINKGO KETO ESTER TABLET AND PREPARATION METHOD THEREFOR
  申请人：SPH Xing Ling Sci. & Tech. Pharmaceutical Co., Ltd.

  公开号：EP3842054A1

  公开（公告）日：2021-06-30

  Provided are a ginkgo keto ester tablet, preparation method therefor, and use thereof. The ginkgo keto ester tablet is prepared by mixing a raw material of ginkgo keto ester and auxiliary materials. On the basis that the total weight of the ginkgo keto ester tablet is 0.25-0.26 g, the following conditions are met: the content of rutin is less than or equal to 1.60 mg per tablet; the content of rutinoside is less than or equal to 0.160 mg per tablet; the content of bilobalide is 1.04-2.08 mg per tablet; the content of ginkgolide J is 0.04-0.2 mg per tablet; the content of alcohol residue is less than or equal to 0.2 mg per tablet; the content of biflavone is less than or equal to 0.008 mg per tablet; and the contents of genistin and ginkgolide M are both 0.

  本发明提供了一种银杏酮酯片剂、其制备方法及其用途。银杏酮酯片剂由银杏酮酯原料和辅料混合制备而成。在银杏酮酯片剂总重量为0.25-0.26克的基础上，满足以下条件：芦丁含量小于等于1.60毫克/片；芦丁苷含量小于等于0.160毫克/片；双叶皂苷含量为1.银杏内酯 J 的含量为 0.04-0.2 毫克/片；醇残渣的含量小于或等于 0.2 毫克/片；双黄酮的含量小于或等于 0.008 毫克/片；染料木苷和银杏内酯 M 的含量均为 0.008 毫克/片。
• Method for controlling pests in soybean
  申请人：BASF SE

  公开号：US10165778B2

  公开（公告）日：2019-01-01

  A method for controlling pests of soybean plants comprises the step of contacting the soybean plant, parts of it, its propagation material, the pests, their food supply, habitat or breeding grounds with one or more components of the ginkgo tree selected from the group consisting of bilobalide, ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J and ginkgolide M.

  一种控制大豆植物害虫的方法包括以下步骤：将大豆植物、其部分、其繁殖材料、害虫、其食物供应、栖息地或繁殖地与银杏树的一种或多种成分接触，这些成分选自双叶银杏内酯、银杏内酯 A、银杏内酯 B、银杏内酯 C、银杏内酯 J 和银杏内酯 M 组成的组。
• Use of pesticidal active carboxamide derivative in soil and seed application and treatment methods
  申请人：BASF Agrochemical Products B.V.

  公开号：US10201157B2

  公开（公告）日：2019-02-12

  The present invention relates to agricultural methods and the use of an insecticidal active carboxamide derivative in seed treatment and soil application methods. The insecticidal carboxamide derivative is highly suitable alone or in combination with other active agricultural ingredients for controlling animal pests such as insects and/or spider mites and/or nematodes by treating the soil/growth substrate by drenching or drip application or dipping or soil injection.

  本发明涉及农业方法和杀虫活性羧酰胺衍生物在种子处理和土壤施用方法中的用途。 杀虫活性羧酰胺衍生物非常适合单独使用或与其他活性农用成分结合使用，通过淋施、滴施、浸渍或土壤注射处理土壤/生长基质，控制动物害虫，如昆虫和/或蜘蛛螨和/或线虫。