Benzene, 1,3-dichloro-5-methyl-2-(1-methylethyl)- | 81686-45-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Benzene, 1,3-dichloro-5-methyl-2-(1-methylethyl)-
• 英文别名: 1,3-dichloro-5-methyl-2-propan-2-ylbenzene
• CAS: 81686-45-5
• 化学式: C₁₀H₁₂Cl₂
• 分子量: 203.1
• InChiKey: LUFVZNQUIZOJJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES CONTAINING THE SAME AS ACTIVE INGREDIENTS
  申请人：MITSUI CHEMICALS AGRO, INC.

  公开号：US20200196600A1

  公开（公告）日：2020-06-25

  A pyridone compound represented by Formula (1): wherein R1, R2, X, Y and Z are defined. The pyridone compound can control plant diseases.

  一种由化学式（1）表示的吡啶酮化合物：其中R1、R2、X、Y和Z被定义。该吡啶酮化合物可以控制植物疾病。
• [EN] C-TERMINAL SRC KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASE SRC C-TERMINALE
  申请人：INVENTISBIO SHANGHAI LTD

  公开号：WO2020125615A1

  公开（公告）日：2020-06-25

  Provided herein are novel C-terminal Srk Kinase (CSK) inhibitors, e.g., having Formula G, I, II, or III. Also provided are methods of preparing the novel CSK inhibitors and method of using the novel CSK inhibitors for treating diseases or disorder such as cancer or for promoting immune response in a subject in need thereof. (G)

  本文提供了新型C端Srk激酶（CSK）抑制剂，例如具有G、I、II或III式的抑制剂。还提供了制备新型CSK抑制剂的方法以及利用这些新型CSK抑制剂治疗癌症等疾病或紊乱的方法，或者用于促进需要的主体的免疫反应。
• N-Phenyloxamide derivatives
  申请人：YAMAGUCHI Youichi

  公开号：US20080249175A1

  公开（公告）日：2008-10-09

  A compound represented by the following general formula (I) or a salt thereof, or a hydrate thereof or a solvate thereof having an inhibitory action against plasminogen activator inhibitor-1 (PAI-1): wherein R 1 represents a C 6-10 aryl group; or a C 6-10 aryl group substituted with a group or groups selected from the group consisting of a halogen atom, cyano group, nitro group, a C 1-6 alkyl group, a halogenated C 1-6 alkyl group, a C 1-6 alkoxy group, a halogenated C 1-6 alkoxy group and a C 1-6 alkylsulfanyl group, R 2 represents a C 6-10 aryl group; or a C 6-10 aryl group substituted with a group or groups selected from the group consisting of a halogen atom, hydroxy group, a C 1-6 alkyl group, a halogenated C 1-6 alkyl group, a C 1-6 alkoxy group, a halogenated C 1-6 alkoxy group, a C 1-6 alkylsulfanyl group and phenyl group, X represents a single bond or oxygen atom, Z represents a phenylene group or a substituted phenylene group, m represents 0 or 1.

  由以下一般式(I)表示的化合物或其盐，或其水合物或其溶剂合物，具有对纤溶酶原激活酶抑制剂-1（PAI-1）的抑制作用：其中R1表示一个C6-10芳基团；或一个C6-10芳基团，该芳基团取代为从卤原子、氰基、硝基、C1-6烷基、卤代C1-6烷基、C1-6烷氧基、卤代C1-6烷氧基和C1-6烷基硫基等组成的组或组合物，R2表示一个C6-10芳基团；或一个C6-10芳基团，该芳基团取代为从卤原子、羟基、C1-6烷基、卤代C1-6烷基、C1-6烷氧基、卤代C1-6烷氧基、C1-6烷基硫基和苯基等组成的组或组合物，X表示一个单键或氧原子，Z表示一个苯基或取代苯基，m表示0或1。
• IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
  申请人：Lai Yingjie

  公开号：US20130096104A1

  公开（公告）日：2013-04-18

  The invention provides compounds of Formulas Ia-Ib, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R 1 , R 2 , R 4 , R 5 and R 16 are defined herein, a pharmaceutical composition that includes a compound of Formulas Ia-Ib and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of using the compound or composition in therapy, as an inhibitor of TYK2 kinase and conditions related, such as inflammatory illnesses, inflammatory bowel disease or psoriasis.

  本发明提供了公式Ia-Ib的化合物、立体异构体或其药学上可接受的盐，其中A、X、R1、R2、R4、R5和R16在此定义，一种包括公式Ia-Ib化合物和药学上可接受的载体、佐剂或车载物的药物组合物，以及使用该化合物或组合物作为TYK2激酶的抑制剂和相关疾病的治疗方法，例如炎症性疾病、炎症性肠病或牛皮癣。
• DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS
  申请人：Sengupta Prabal

  公开号：US20130296557A1

  公开（公告）日：2013-11-07

  The present invention relates to novel diarylacetylene hydrazide compounds of formula (I) or pharmaceutically acceptable salt thereof, as tyrosine kinase inhibitors, the process for their preparation, and to the use of the compounds of formula (I) in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders related to tyrosine kinases, in warm-blooded animals

  本发明涉及一种新颖的二芳基乙炔基腙化合物，其化学式为(I)，或其药学上可接受的盐，作为酪氨酸激酶抑制剂，其制备过程，以及将化合物(I)用于制备与温血动物的酪氨酸激酶相关疾病的治疗药物组合物。