1-(4-iso-Propylphenyl)-2-propanol | 105994-80-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-(4-iso-Propylphenyl)-2-propanol
• 英文别名: 1-(4-propan-2-ylphenyl)propan-2-ol
• CAS: 105994-80-7
• 化学式: C₁₂H₁₈O
• 分子量: 178.27
• InChiKey: OYDGTBAXIOLNFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE<br/>[FR] INHIBITEURS DE L'INDOLÉAMINE 2,3-DIOXYGÉNASE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2020023355A1

  公开（公告）日：2020-01-30

  The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

  本发明提供了以下化合物（I）的公式：其中所有变量如本文所定义。这些化合物是色氨酸2,3-二氧化酶（IDO）的抑制剂，可用作治疗增殖性疾病，如癌症、病毒感染和/或自身免疫疾病的药物。
• Process for producing alkylene oxide
  申请人：Murray Dermot Brendan

  公开号：US20050020840A1

  公开（公告）日：2005-01-27

  A process for preparing an alkylene oxide, which process comprises: (i) oxidizing an alkylbenzene to obtain a stream comprising alkylbenzene hydroperoxide, (ii) contacting at least part of the alkylbenzene hydroperoxide obtained in step (i) with an olefin to obtain a product stream comprising an alkylene oxide (iii) separating alkylene oxide compound from the product stream of step (ii) to obtain (a) a residual product stream comprising alkylphenyl alcohol, and (b) alkylene oxide, (iv) feeding at least a part of the residual product stream comprising alkylphenyl alcohol to a reactor having a catalytic distillation zone, and concurrently in the reactor, (a) contacting the residual product stream comprising alkylphenyl alcohol with hydrogen in the catalytic distillation zone to convert the alkylphenyl alcohol in the residual product stream to alkylbenzene and form a reaction mixture, and (b) separating alkylbenzene from the reaction mixture by fractional distillation, (v) withdrawing a stream comprising alkylbenzene and having a reduced concentration of alkylphenyl alcohol than the feed stream from the reactor at a position upper from the catalytic reaction zone; (vi) withdrawing from the reactor at a position lower than the catalytic distillation zone a bottom stream comprising dimer(s) of alkylbenzene; (vii) converting the dimer(s) of alkylbenzene in the bottom stream from (vi) to alkylbenzene; and (viii) recycle at least a part of the alkylbenzene produced from (iv)(b) and/or (vi) to step (i).

  制备烷基氧化物的过程，包括以下步骤：(i)将烷基苯氧化以获得含有烷基苯羟基过氧化物的流，(ii)将步骤(i)获得的至少部分烷基苯羟基与烯烃接触，以获得含有烷基氧化物的产物流，(iii)从步骤(ii)的产物流中分离烷基氧化物化合物，以获得(a)含有烷基苯酚的残余产物流，和(b)烷基氧化物，(iv)将至少部分含有烷基苯酚的残余产物流馈送到具有催化精馏区的反应器中，并在反应器中同时进行以下操作：(a)在催化精馏区中将含有烷基苯酚的残余产物流与氢气接触，将残余产物流中的烷基苯酚转化为烷基苯并形成反应混合物，(b)通过分馏将烷基苯从反应混合物中分离出来，(v)从反应器中在催化反应区域上方的位置提取含有降低烷基苯酚浓度的烷基苯流，(vi)从反应器中在催化精馏区域下方的位置提取含有烷基苯二聚体的底流，(vii)将步骤(vi)中底流中的烷基苯二聚体转化为烷基苯，(viii)回收至少部分从步骤(iv)(b)和/或步骤(vi)生产的烷基苯，回收至步骤(i)。
• Oxidation process of aromatic compounds
  申请人：KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0267759A2

  公开（公告）日：1988-05-18

  An aromatic compound selected from benzene and biphenyl compounds containing at least one isopropyl group is oxidized to convert at least one of the at least one isopropyl group into a 2-hydroxy-2-propyl group. The oxidation of the aromatic compound is effected with molecular oxygen in the presence of an aqueous alkali solution in an oxidative reaction vessel made of nickel at parts thereof where the vessel comes into contact with a reaction mixture. In particular, the above process suppresses the formation of byproducts and permits long-term oxidation on an industrial scale.

  一种芳香族化合物，选自苯和含有至少一个异丙基的联苯化合物，通过氧化将至少一个异丙基转化为 2-羟基-2-丙基。 芳香族化合物的氧化是在镍制成的氧化反应容器中，在该容器与反应混合物接触的部位，在碱水溶液存在下，用分子氧进行的。 特别是，上述工艺可抑制副产物的形成，并允许在工业规模上进行长期氧化。
• Volatile applications against pathogens
  申请人：AGROFRESH INC.

  公开号：US10765117B2

  公开（公告）日：2020-09-08

  This invention is related to the use of a volatile antimicrobial compound against pathogens affecting humans comprising contacting infected areas with an atmosphere containing an effective amount of a volatile antimicrobial compound in gaseous form. The volatile antimicrobial compounds provided include certain oxaborole compounds, for example benzoxaboroles. Delivery systems are provided to take advantage of the volatile nature of these antimicrobial compounds. The method and use disclosed can be combined with other volatile compounds.

  本发明涉及使用挥发性抗菌化合物来对付影响人类的病原体，包括使受感染区域与含有有效量气态挥发性抗菌化合物的环境接触。所提供的挥发性抗菌化合物包括某些氧硼化合物，例如苯并氧硼化合物。提供的给药系统可利用这些抗菌化合物的挥发性。所公开的方法和用途可与其他挥发性化合物结合使用。
• Process for producing alkylbenzene
  申请人：Murray Dermot Brendan

  公开号：US20050054890A1

  公开（公告）日：2005-03-10

  A process for producing an alkylbenzene from an alkylphenyl alcohol involving the steps of: (a) feeding a feed stream containing alkylphenyl a reactor having a catalytic distillation zone; and, (b) concurrently in the reactor (i) contacting the feed stream containing alkylphenyl alcohol with hydrogen in the catalytic distillation zone to convert alkylphenyl alcohol to alkylbenzene over a catalyst containing Group VIII or a Group IB metal; and, (ii) separating alkylbenzene from the reaction mixture by fractional distillation to produce an overhead stream containing alkylbenzene having a reduced concentration of alkylphenyl alcohol than the feed stream from the distillation column reactor. Examples of the alkylphenyl alcohol include cumyl alcohol, phenyl ethyl alcohol, or di(2-hydroxyl 2-propyl)benzene, and that for the alkylbenzene include cumene and di-ethyl benzene, or di(2-hydroxyl-2-propyl)benzene.

  一种用烷基苯醇生产烷基苯的工艺，包括以下步骤(a) 将含有烷基苯的进料流送入具有催化蒸馏区的反应器；以及，(b) 同时在反应器中，(i) 在催化蒸馏区将含有烷基苯醇的进料流与氢接触，以便在含有 VIII 族或 IB 族金属的催化剂作用下将烷基苯醇转化为烷基苯；以及，(ii) 通过分馏将烷基苯从反应混合物中分离出来，生成含有烷基苯的顶流，该顶流的烷基苯醇浓度低于来自蒸馏塔反应器的进料流。烷基苯醇的例子包括积醇、苯乙醇或二(2-羟基-2-丙基)苯，烷基苯的例子包括积苯和二乙基苯或二(2-羟基-2-丙基)苯。