[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-2-yl]methyl (4-nitrophenyl) carbonate | 497959-05-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-2-yl]methyl (4-nitrophenyl) carbonate
• CAS: 497959-05-4
• 化学式: C₂₃H₁₉ClN₂O₇S
• 分子量: 502.932
• InChiKey: AVEQPLHAFOAAHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  127
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  [1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-2-yl]methyl (4-nitrophenyl) carbonate 、 1-(3-氨基丙基)吡咯烷 以 甲醇 为溶剂， 生成 [1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-2-yl]methyl N-(3-pyrrolidin-1-ylpropyl)carbamate
  参考文献：
  名称：

  Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

  摘要：

  The development of a novel series of tetrahydroquinoline-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.09.064
• 作为产物：
  描述：

  1,2,3,4-四氢-2-喹啉甲醇 在 吡啶 、 甲醇 、 potassium carbonate 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙腈 为溶剂， 生成 [1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-2-yl]methyl (4-nitrophenyl) carbonate
  参考文献：
  名称：

  Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

  摘要：

  The development of a novel series of tetrahydroquinoline-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.09.064

文献信息

• NOVEL GAMMA SECRETASE INHIBITORS
  申请人：Schering Corporation

  公开号：EP1492765B1

  公开（公告）日：2011-07-06
• [EN] NOVEL GAMMA SECRETASE INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE GAMMA-SECRETASE
  申请人：SCHERING CORP

  公开号：WO2003014075A2

  公开（公告）日：2003-02-20

  This invention discloses novel gamma secretase inhibitors of the formula:(Chemical formula should be inserted here as it appears on abstract in paper form)wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 is an R1 group, alkyl, -X(CO)Y, -(CR32)1-4X(CO)Y; each R3A is independently H or alkyl; X is -O-, -NH, or -N-alkyl; and Y is -NR6R7, or -N(R3)(CH2)2-6NR6R7. Also disclosed is a method of treating Alzheimer s Disease.
• Tetrahydroquinoline sulfonamides as γ-secretase inhibitors
  作者：Theodros Asberom、Thomas A. Bara、John W. Clader、William J. Greenlee、Henry S. Guzik、Hubert B. Josien、Wei Li、Eric M. Parker、Dmitri A. Pissarnitski、Lixin Song、Lili Zhang、Zhiqiang Zhao

  DOI：10.1016/j.bmcl.2006.09.064

  日期：2007.1

  The development of a novel series of tetrahydroquinoline-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described. (c) 2006 Elsevier Ltd. All rights reserved.