6-(1,2-Dithiolan-3-yl)hexan-2-one | 643020-98-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二硫杂环戊烷
• 英文名称: 6-(1,2-Dithiolan-3-yl)hexan-2-one
• 英文别名: 6-(dithiolan-3-yl)hexan-2-one
• CAS: 643020-98-8
• 化学式: C₉H₁₆OS₂
• 分子量: 204.4
• InChiKey: RDSXLEZBUWOKSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  67.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] NSAIDs DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS D'ANTI-INFLAMMATOIRES NON STÉROÏDIENS (AINS) ET LEURS UTILISATIONS
  申请人：UNIV CITY NEW YORK RES FOUND

  公开号：WO2014124208A1

  公开（公告）日：2014-08-14

  The present invention discloses novel compounds derived from NSAIDs and pharmaceutically acceptable salts thereof. Other aspects of the invention relate to use of the NSAID derivatives in treating inflammatory diseases and pharmaceutical compositions thereof. Non-steroidal anti-inflammatory drugs (NSAIDs) are prototypical agents for treatment of inflammatory conditions. NSAIDs may also have utility as therapeutic agents against many forms of cancers. However, long-term use of NSAIDs may lead to serious side effects affecting the gastrointestinal and renal systems.

  本发明公开了源自非甾体抗炎药（NSAIDs）的新化合物及其药用可接受的盐。发明的其他方面涉及使用这些非甾体抗炎药衍生物来治疗炎症性疾病以及相应的药物组合物。非甾体抗炎药（NSAIDs）是治疗炎症状况的典型药物。NSAIDs还可能作为许多形式癌症的治疗剂而具有实用价值。然而，长期使用NSAIDs可能会导致影响胃肠和肾脏系统的严重副作用。
• 1,2,3-TRIAZOLE-BASED PEPTIDOMIMETIC INTEGRIN INHIBITORS FOR THE DIAGNOSIS AND THERAPY OF TUMORS
  申请人：Guarna Antonio

  公开号：US20130040964A1

  公开（公告）日：2013-02-14

  The present invention refers to the field of chemical compounds bearing a 1,2,3-triazole ring of formula (I) and possessing guanidino and carboxylic groups or their isosteres, their preparation by Cu-catalyzed “click-chemistry”, and medical-diagnostic use in pathologies where angiogenesis is altered, for example pathologic conditions of tumor origin, tumor metastasis, osteoporosis, and rheumatoid arthritis.

  本发明涉及具有化学化合物的领域，其具有1,2,3-三唑环的结构（I）并且具有胍基和羧基或其同分异构体，通过铜催化的“点击化学”方法制备这些化合物，并在血管生成异常的病理学中进行医学诊断使用，例如肿瘤起源的病理性状况、肿瘤转移、骨质疏松症和类风湿性关节炎。
• Novel esters of lipoic acid
  申请人：Lawrence J. Lowell

  公开号：US20070055070A1

  公开（公告）日：2007-03-08

  A process is provided for producing lipoate esters from α-lipoic acid. The process comprises reacting α-lipoic acid with an alcohol and then adding a polymerization inhibitor such as L-cysteine.

  提供一种从α-硫辛酸生产脂酸酯的过程。该过程包括将α-硫辛酸与醇反应，然后加入聚合抑制剂，如L-半胱氨酸。
• SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) COMPOUNDS AND METHODS OF THEIR PREPARATION
  申请人：CHANG Young-Tae

  公开号：US20120128592A1

  公开（公告）日：2012-05-24

  A compound for detecting an analyte using Surface Enhanced Raman Spectroscopy (SERS) and a method of forming the compound is provided. The compound has Formula I: wherein W is selected from the group consisting of an optionally substituted aryl group and an optionally substituted heteroaryl group; each Y independently is NR 1 R 2 , wherein R 1 and R 2 are independently selected from the group consisting of H and C 1 -C 6 alkyl, or R 1 and R 2 combine to form together with the nitrogen to which they are attached a heterocyclic group with 4 to 5 carbon atoms, is used to denote a single or a double bond, and Z is NH, NH 2 , NH—(C═O)—(CH 2 ) n —SH, wherein n=1 to 10, or or a tautomer or stereoisomer thereof, or a salt thereof. A method and device for detecting an analyte using Surface Enhanced Raman Spectroscopy (SERS) is also provided.

  提供了一种利用表面增强拉曼光谱（SERS）检测分析物的化合物以及形成该化合物的方法。该化合物具有式I：其中W从可选择的取代芳基和可选择的取代杂环基组成的组中选择；每个Y独立地为NR1R2，其中R1和R2独立地从H和C1-C6烷基组成的组中选择，或者R1和R2与它们连接的氮原子一起形成含有4到5个碳原子的杂环基，表示单键或双键，Z为NH、NH2、NH—(C═O)—(CH2)n—SH，其中n=1到10，或其异构体或立体异构体，或其盐。还提供了一种利用表面增强拉曼光谱（SERS）检测分析物的方法和装置。
• NOVEL METHYLENEDIOXY PHENOLIC COMPOUNDS AND THEIR USE TO TREAT DISEASE
  申请人：Parthasarathy Sampath

  公开号：US20100035849A1

  公开（公告）日：2010-02-11

  The present invention provides novel methylenedioxy phenolic compounds and their derivatives, methods of making them and methods of using them to treat or prevent cardiovascular disease, vascular disease and/or inflammatory disease, as well as Type I and Type II Diabetes and Dyslipidemia patients at risk for hypertension, stroke, cardiovascular and renal disease.

  本发明提供了新型亚甲二氧苯酚化合物及其衍生物，制备它们的方法以及利用它们治疗或预防心血管疾病、血管疾病和/或炎症性疾病的方法，以及治疗 1 型和 2 型糖尿病和血脂异常患者，这些患者有高血压、中风、心血管和肾脏疾病的风险。