[(1R)-3-bromo-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]methanesulfonic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(1R)-3-bromo-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]methanesulfonic acid
• 化学式: C₁₀H₁₅BrO₄S
• 分子量: 311.19
• InChiKey: XUJHKPSBHDQIOD-QIMWKCOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL PROCESS FOR THE PREPARATION OF 1,3-THIAZOL-5-YLMETHYL [(2R,5R)-5- CARBAMOYL) AMINO] -4-(MORPHOLIN-4-YL)BUTANOYL]AMINO}-1,6-DIPHENYLHEXAN-2-YL]CARBAMATE
  申请人：THIRUMALAI RAJAN Srinivasan

  公开号：US20180030043A1

  公开（公告）日：2018-02-01

  The present invention relates to novel processes for the preparation 1,3-Thiazol-5-ylmethyl[(2R,5R)-5-[(2S)-2-[(methyl[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl} carbamoyl)amino]-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl] carbamate having the following structural formula-1 and it's intermediates thereof.

  本发明涉及用于制备具有以下结构式-1的1,3-噻唑-5-基甲基[(2R,5R)-5-[(2S)-2-[(甲基[2-(丙-2-基)-1,3-噻唑-4-基]甲基}氨基甲酰基)氨基]-4-(吗啉-4-基)丁酰基]氨基}-1,6-二苯基己烷-2-基]碳酸盐及其中间体的新工艺。
• Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP2599781A1

  公开（公告）日：2013-06-05

  There is provided salts and polymorphs of sitagliptin, processes for the preparation thereof, and pharmaceutical compositions comprising the same.

  提供了西格列汀的盐和多晶形式，其制备方法以及包含它们的制药组合物。
• PROCESSES FOR THE PREPARATION OF SITAGLIPTIN AND PHARMACEUTICLLY ACCEPTABLE SALTS THEREOF
  申请人：Padi Pratap Reddy

  公开号：US20100274017A1

  公开（公告）日：2010-10-28

  There is provided salts and polymorphs of sitagliptin, processes for the preparation thereof, and pharmaceutical compositions comprising the same.

  提供了西格列汀的盐和多晶形态，以及其制备方法和包含其的药物组合物。
• PROCESSES FOR THE PREPARATION OF SITAGLIPTIN AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
  申请人：DR. REDDY'S LABORATORIES LIMITED

  公开号：US20130035486A1

  公开（公告）日：2013-02-07

  There is provided salts and polymorphs of sitagliptin, processes for the preparation thereof, and pharmaceutical composition comprising the same.

  提供了西格列汀的盐和多晶形态，其制备方法以及包含其的药物组合物。
• PROCESS FOR THE PREPARATION OF EXAMETAZIME
  申请人：Jubilant Life Sciences Limited

  公开号：US20170015620A1

  公开（公告）日：2017-01-19

  The present invention provides an improved process for the preparation of exametazime, which is used as ligand in preparation of technetium-99m complex.

  本发明提供了一种改进的制备考昔昔的过程，该过程用作铼-99m配合物制备中的配体。