(1R,7S)-8-(hydroxy-phenyl-pyridin-2-ylmethyl)-10-[phenyl(pyridin-2-yl)methylidene]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione | 991-42-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R,7S)-8-(hydroxy-phenyl-pyridin-2-ylmethyl)-10-[phenyl(pyridin-2-yl)methylidene]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
• CAS: 991-42-4
• 化学式: C₃₃H₂₅N₃O₃
• 分子量: 511.6
• InChiKey: DNTHHIVFNQZZRD-YBQNZOIUSA-N

物化性质

• 熔点：
  190-198°
• 沸点：
  598.31°C (rough estimate)
• 密度：
  1.2065 (rough estimate)
• 溶解度：
  氯仿（微溶）、甲醇（微溶、加热）
• 物理描述：
  Norbormide is a colorless to off-white crystalline powder. Used as a selective rat poison. (EPA, 1998)
• 颜色/状态：
  CRYSTALS FROM METHYLENE CHLORIDE + ETHER
• 稳定性/保质期：
  IT IS...STABLE @ ROOM TEMP WHEN DRY, AND TO BOILING WATER; HYDROLYZED BY ALKALI.
• 分解：
  WHEN HEATED TO DECOMPOSITION IT EMITS TOXIC FUMES OF NOx.
• 腐蚀性：
  Non-corrosive

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  39
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  92.2
• 氢给体数：
  2
• 氢受体数：
  5

ADMET

毒理性

• 解毒与急救

立即进行急救：确保已经进行了充分的中毒物清洗。如果受害者停止呼吸，开始进行人工呼吸，最好使用训练过的需求阀复苏器、袋阀面罩装置或口袋面罩。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者身体前倾或置于左侧（如果可能的话，头部向下），以保持呼吸道畅通，防止吸入性肺炎。保持受害者安静，维持正常体温。寻求医疗帮助。/毒物A和B/

For immediate first aid: Ensure that adequate decontamination has been carried out. If victim is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep victim quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……监测休克，如有必要，进行治疗……预见并治疗癫痫发作……眼睛污染时，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……不要使用催吐剂。对于误食，如果患者能吞咽、有强烈的呕吐反射且不流口水，则用水冲洗口腔，并给予5毫升/千克、最多200毫升的水进行稀释……在去污后，用无菌敷料覆盖皮肤烧伤……/毒药A和B/

For basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... Monitor for shock and treat if necessary ... Anticipate seizures and treat if necessary ... For eye contamination, flush eye immediately with water. Irrigate each eye continuously with normal saline during transport ... Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. ... Cover skin burns with sterile dressings after decontamination ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

三名成年男性志愿者每天接受15毫克/千克的剂量，连续3天，没有出现不良反应。

THREE ADULT MALE VOLUNTEERS RECEIVED 15 MG/KG DAILY FOR 3 DAYS WITHOUT ILL-EFFECT.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

人类摄入剂量高达300毫克时，会出现轻微短暂的体温和血压下降。皮内注射（0.1毫升0.1%溶液）在人体中没有产生皮肤反应或病变。

HUMANS INGESTING DOSES UP TO 300 MG SHOWED SLIGHT TRANSIENT DECR IN BODY TEMP & BLOOD PRESSURE. INTRADERMAL INJECTIONS (0.1 ML OF 0.1% SOLN) PRODUCED NO SKIN REACTIONS OR LESIONS IN MAN.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

一名妇女在倾倒杀虫剂溶液以制作灭鼠毒饵时，出现了接触性皮炎的病例。溶液沾到了她的双手、右膝和左前臂的皮肤上。在那里，出现了急性皮肤炎症的迹象，以及由溶液刺激特性引起的慢性皮肤病的临床图片。

A case of contact dermatitis is described on a woman who poured over pesticide solution in order to make poisonous pesticides for rodents. The solution got on the skin of her hands, right crus and left forearm. There the signs of acute skin inflammation appeared along with the clinical picture of chronic dermatosis caused by the solution irritating characteristics.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(a)
• 危险品标志：
  Xn
• 安全说明：
  S26,S36/37/39,S45
• 危险类别码：
  R22
• WGK Germany：
  3
• 危险类别：
  6.1(a)
• 危险品运输编号：
  2588

制备方法与用途

类别：农药
毒性分级：剧毒
急性毒性：口服-大鼠 LD50: 3.8 毫克/公斤；口服-小鼠 LD50: 2.25 毫克/公斤
可燃性危险特性：受热分解产生有毒的氧化氮气体
储运特性：应存放在通风、低温和干燥的库房中，并与食品原料分开存放和运输
灭火剂：砂土、干粉、泡沫