2-succinamido 2-deoxy β-D-glucose | 129778-15-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-succinamido 2-deoxy β-D-glucose
• 英文别名: glucosamine-succinic anhydride；CGlc；4-oxo-4-[[(2R,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]amino]butanoic acid
• CAS: 129778-15-0
• 化学式: C₁₀H₁₇NO₈
• 分子量: 279.247
• InChiKey: YCADUTALRCFWBJ-GKKUVZKPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  157
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-benzylsuccinamido 2-deoxy 1,3,4,6-tetra O-acetyl β-D-glucose 在 palladium on activated charcoal 氢气 、 sodium methylate 作用下， 以 甲醇 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 5.5h， 生成 2-succinamido 2-deoxy β-D-glucose
  参考文献：
  名称：

  D-氨基葡萄糖的4-羟基丁酸（及其类似物）衍生物

  摘要：

  描述了2-羧酰胺基2-脱氧的1,3,4,6-四O-乙酰基β-D-葡萄糖和2-羧酰胺基2-脱氧D-葡萄糖的衍生物的合成。这些化合物被提议作为4-羟基丁酸（GHB）衍生物，以试图测试GHB结构的修饰是否可以导致更具活性的生物物质。

  DOI：

  10.1016/s0040-4020(01)85793-8

文献信息

• GLUCOSAMINE DERIVATIVE NANOPARTICLE AND PREPARATING METHOD AND USE THEREOF
  申请人：CPC Corporation, TAIWAN

  公开号：US20240228525A1

  公开（公告）日：2024-07-11

  The present invention discloses a glucosamine derivative nanoparticle and preparation method and use thereof. By self-assembling glucosamine derivatives and ethanol into the form of nanoparticles, the skin penetration rate and cell absorption rate of glucosamine are improved, and at the same time the toxicity to cells and organisms is reduced. The problem of poor absorption of glucosamine is improved by using glucosamine derivative nanoparticles. Furthermore, the glucosamine derivative nanoparticles can be used as a delivery carrier to cover and bring the specified ingredients into the cells or stratum corneum, and to increase the skin penetration rate and cell absorption rate of the specified ingredients.
• 4-Hydroxybutyric acid (and analogues) derivatives of D-glucosamine
  作者：F. Dardoize、C. Goasdoué、N. Goasdoué、H.M. Laborit、G. Topall

  DOI：10.1016/s0040-4020(01)85793-8

  日期：——

  The syntheses of 2-carboxamido 2-deoxy 1,3,4,6-tetra O-acetyl β-D-glucose and 2-carboxamido 2-deoxy D-glucose derivatives are described. These compounds are proposed as 4-hydroxybutyric acid (GHB) derivatives in attempt to test whether modifications in GHB structure could lead to more active biological substances.

  描述了2-羧酰胺基2-脱氧的1,3,4,6-四O-乙酰基β-D-葡萄糖和2-羧酰胺基2-脱氧D-葡萄糖的衍生物的合成。这些化合物被提议作为4-羟基丁酸（GHB）衍生物，以试图测试GHB结构的修饰是否可以导致更具活性的生物物质。