[4-(1,3-苯并恶唑-2-基)苯基]甲醇 | 421553-38-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: [4-(1,3-苯并恶唑-2-基)苯基]甲醇
• 英文名称: 2-(4-hydroxymethylphenyl)benzoxazole
• 英文别名: [4-(1,3-benzoxazol-2-yl)phenyl]methanol；4-(benzoxazol-2-yl)benzyl alcohol；2-(4'-hydroxymethyl)phenyl-1,3-benzoxazole；4(benzoxazol-2-yl)benzyl alcohol
• CAS: 421553-38-0
• 化学式: C₁₄H₁₁NO₂
• 分子量: 225.247
• InChiKey: BQKZFFYLVOZEPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [4-(1,3-苯并恶唑-2-基)苯基]甲醇 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 32.0h， 生成 [4-(1,3-benzoxazol-2-yl)phenyl]methyl N-[(3S)-2-oxoazetidin-3-yl]carbamate
  参考文献：
  名称：

  [EN] CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS
  [FR] DÉRIVÉS DE CARBAMATE D'INHIBITEURS D'AMIDASE ACIDE DE N-ACYLÉTHANOLAMINE (NAAA) À BASE DE LACTAME

  摘要：

  公开号：

  WO2014144836A3
• 作为产物：
  描述：

  methyl 4-(benzo[d]oxazol-2-yl)benzoate 在 Rochelle's salt 、 magnesium sulfate 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以to give the title alcohol (0.16 g, 89%)的产率得到[4-(1,3-苯并恶唑-2-基)苯基]甲醇
  参考文献：
  名称：

  Chemokine receptor binding heterocyclic compounds

  摘要：

  公开了调节趋化因子受体活性的化合物。这些化合物通常为三级胺，包括四氢喹啉和苯并咪唑。

  公开号：

  US06734191B2

文献信息

• Aliphatic amino bis-aryl squalene synthase inhibitors
  申请人：Rhone-Poulenc Rorer Pharmaceuticals Inc.

  公开号：US05455260A1

  公开（公告）日：1995-10-03

  This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

  这项发明涉及一类新型的脂肪族氨基双芳基化合物，其中至少含有四个碳原子和一个氨基团，该氨基团可以被取代或者内含，并且进一步连接或者桥接到两个单环和/或双环环。这项发明的化合物在不显著降低麦角甾醇代谢产物合成的情况下，降低体内血清胆固醇水平。这项发明还涉及使用这些化合物降低血清胆固醇水平的药理组合物和治疗方法。
• Amino Bi- and tri-carbocyclic aklane bis-aryl squalene synthase
  申请人：Rhone-Poulenc Rorer Pharmaceuticals Inc.

  公开号：US05395846A1

  公开（公告）日：1995-03-07

  This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and tri-carbocyclic alkane ring contains an amino group and the ring is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

  本发明涉及一类新型的具有双芳基取代的氨基双环和三环烷烃化合物，具有角鲨烯合酶抑制性能。双环和三环烷环中含有一个氨基团，并且该环进一步与一个或两个单环和/或双环环相连或桥接。本发明的化合物能够降低体内的血清胆固醇水平，而不会显著减少戊二酸代谢物的合成。本发明还涉及使用本发明的化合物降低血清胆固醇水平的药物组合物和治疗方法。
• HETEROCYCLIC INDENE DERIVATIVES AND THEIR RADIOISOTOPE LABELED COMPOUNDS FOR IMAGING BETA-AMYLOID DEPOSITION
  申请人：JEONG Jae Min

  公开号：US20080299041A1

  公开（公告）日：2008-12-04

  The invention is directed to heterocyclic indene derivatives useful for β-amyloid plaque imaging, their radiolabeled compounds and their preparation methods. The compounds of the invention are easily labeled with radioisotopes and have high affinities to β-amyloid depositions, thus they facilitate diagnosis of Alzheimer's disease by imaging the distribution of β-amyloid depositions.

  本发明涉及杂环吲哚衍生物，其可用于β-淀粉样斑块成像，其放射性标记化合物及其制备方法。本发明的化合物易于标记放射性同位素，并具有高亲和力与β-淀粉样沉积物，因此它们通过成像β-淀粉样沉积物的分布，促进阿尔茨海默病的诊断。
• Amino bi- and tri-carbocyclic alkane bis-aryl squalene synthase
  申请人：Rhone-Poulenc Rorer Pharmaceuticals Inc.

  公开号：US05596020A1

  公开（公告）日：1997-01-21

  This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and tri-carbocyclic alkane ring contains an amino group and the ring is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

  本发明涉及一类新型氨基双和三环烷化合物，其具有双芳基取代基，表现出鱼肝油合成酶抑制特性。双和三环烷基环包含一个氨基团，并且该环进一步连接或桥接到两个单环和/或双环。本发明的化合物可以降低体内血清胆固醇水平，而不会显著降低甲烷代谢物合成。本发明还涉及药理组合物和使用本发明化合物降低血清胆固醇水平的治疗方法。
• CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS
  申请人：The Regents of the University of California

  公开号：US20160068482A1

  公开（公告）日：2016-03-10

  Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.

  本文描述了一些化合物和药物组成物，它们可以抑制N-酰基乙醇胺酸酰化酶（NAAA）。本文还描述了合成这些化合物的方法，以及将它们制成药物组成物的方法。同时，本文还描述了抑制NAAA以维持棕榈酰乙醇胺（PEA）和其他N-酰基乙醇胺（NAE）的水平的方法，这些物质是NAAA的底物，并且在NAE浓度降低的情况下有用。此外，本文还描述了治疗和缓解疼痛、炎症、炎症性疾病和其他疾病的方法，这些疾病中脂肪酸乙醇胺的调节在临床或治疗上是相关的，或者NAE的浓度降低与该疾病有关。