tamsulosin (+)-camphor-10-sulfonate | 1174232-94-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: tamsulosin (+)-camphor-10-sulfonate
• 英文别名: (7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl)methanesulfonic acid;5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
• CAS: 1174232-94-0
• 化学式: C₁₀H₁₆O₄S*C₂₀H₂₈N₂O₅S
• 分子量: 640.819
• InChiKey: FATAUKZYLUTXMK-XFULWGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.61
• 重原子数：
  43
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  188
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• Process for resolution of tamsulosin and compounds, compositons, and processes associated therewith
  申请人：——

  公开号：US20030109752A1

  公开（公告）日：2003-06-12

  Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful starting material for the resolution process and a method of obtaining the same in solid form, including two crystalline polymorphic forms, is also provided.

  包括消旋盐酸坦洛新在内的光学不纯的坦洛新可以通过使用坦洛新的对映异构磺酸盐在分馏结晶技术中分离成光学纯的(R)-或(S)-坦洛新。消旋盐酸坦洛新游离碱是分离过程的有用起始物质，同时还提供了一种获得固体形式的方法，包括两种晶态多型形式。
• Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
  申请人：Hoorn J. Hans

  公开号：US20050096394A1

  公开（公告）日：2005-05-05

  Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)— or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful starting material for the resolution process and a method of obtaining the same in solid form, including two crystalline polymorphic forms, is also provided.

  光学不纯的盐酸曲唑酮，包括外消旋的盐酸曲唑酮，可以通过使用曲唑酮的对映异构磺酸盐在分馏结晶技术中被分离成光学纯的(R)或(S)-曲唑酮。外消旋的盐酸曲唑酮自由碱是分离过程中有用的起始材料，并且还提供了一种获得同样的固态形式，包括两种晶态多形的方法。
• Tamsulosin free base and recovery process thereof
  申请人：Synthon B.V.

  公开号：EP1905758A1

  公开（公告）日：2008-04-02

  Racemic tamsulosin free base is obtained in solid form. The solid form can be formed by precipitating racemic tamsulosin free base from a solvent that comprises at least one of water or a lower alcohol. The crystalline free base exhibits polymorphism and two unique forms are identified. Novel intermediates are disclosed useful in the production of tamsulosin free base: a sulfonic acid salt of 2-(o-ethoxyphenoxy)ethylamine and (3-aminosulfonyl-4-methoxy)phenylacetone.

  外消旋坦索罗辛游离碱以固体形式获得。外消旋坦索罗辛游离碱可以从水或低级醇中的至少一种溶剂中析出，形成固体形式。结晶游离碱呈现出多态性，并确定了两种独特的形式。本研究公开了可用于生产游离坦索罗辛碱的新型中间体：2-(邻乙氧基苯氧基)乙胺的磺酸盐和(3-氨基磺酰基-4-甲氧基)苯丙酮。
• RACEMIC TAMSULOSIN FREE BASE AND METHODS OF MAKING THE SAME
  申请人：Synthon B.V.

  公开号：EP1444199A1

  公开（公告）日：2004-08-11
• PROCESS FOR RESOLUTION OF TAMSULOSIN
  申请人：Synthon B.V.

  公开号：EP1444198A1

  公开（公告）日：2004-08-11