Epoxygedunin

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Epoxygedunin
• 英文别名: [(1S,7S,8S,12R,20R)-7-(furan-3-yl)-1,8,12,17,17-pentamethyl-5,16-dioxo-3,6,14-trioxahexacyclo[9.9.0.02,4.02,8.012,18.013,15]icosan-20-yl] acetate
• 化学式: C₂₈H₃₄O₈
• 分子量: 498.6
• InChiKey: AZGNIKZHFDJEPU-FJONONFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  36
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Compositions and methods for neuroprotectin
  申请人：Steiner P. Joseph

  公开号：US20080090897A1

  公开（公告）日：2008-04-17

  Disclosed herein are neuroprotective compounds. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of neurodegenerative conditions are provided.
• Role of limonoid compounds as neuroprotective agents
  申请人：Steiner Joseph P.

  公开号：US20100056617A1

  公开（公告）日：2010-03-04

  Disclosed herein are neuroprotective compounds. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of neurodegenerative conditions are provided.
• Methods and Compositions for Diagnosis and Treatment of Multiple Sclerosis
  申请人：Nath Avindra

  公开号：US20100137420A1

  公开（公告）日：2010-06-03

  Biological markers for multiple sclerosis, and their use in the diagnosis and prognosis of the disease, are described. Also described are methods for treating multiple sclerosis by administering an inhibitor of cathepsin B activity or a neuroprotective composition comprising a modified terpenoid compound. Also described are isolated polypeptide biomarkers, polynucleotides encoding the polypeptide biomarkers, and antibodies that bind specifically to the polypeptide biomarkers. Further described are kits that include the above-mentioned isolated polypeptide biomarkers, the polynucleotides encoding them, or specific antibodies against the polypeptide biomarkers.
• US8114619B2
  申请人：——

  公开号：US8114619B2

  公开（公告）日：2012-02-14
• US9289412B2
  申请人：——

  公开号：US9289412B2

  公开（公告）日：2016-03-22