potassium (E)-3-(4-methoxyphenyl)acrylate | 86636-96-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: potassium (E)-3-(4-methoxyphenyl)acrylate
• 英文别名: Kalium-p-methoxycinnamat；potassium-p-methoxycinnamate；Potassium methoxycinnamate；potassium;(E)-3-(4-methoxyphenyl)prop-2-enoate
• CAS: 86636-96-6
• 化学式: C₁₀H₉O₃*K
• 分子量: 216.278
• InChiKey: OEEUOVDUVFUJCL-KQGICBIGSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.54
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-氯甲基)-5-羟基-4H-吡喃-4-酮 、 potassium (E)-3-(4-methoxyphenyl)acrylate 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以0.28 g的产率得到5-hydroxy-4-oxo-4H-pyran-2-yl-methyl (E)-3-(4-methoxyphenyl)acrylate
  参考文献：
  名称：

  一种酪氨酸酶抑制剂及其应用

  摘要：

  本发明提供了一种羟基氧代吡喃甲基酯类化合物及其在药学上可接受的盐，其具有如下结构式：本发明的羟基氧代吡喃甲基酯类化合物以白藜芦醇和曲酸为原料制备获得，具有良好的酪氨酸抑制剂性能且安全有效，可广泛应用于制备药物、化妆品或果蔬保鲜剂。

  公开号：

  CN110156733B

文献信息

• SKIN EXTERNAL PREPARATIONS AND COSMETICS
  申请人：Aoki Hirobumi

  公开号：US20100280111A1

  公开（公告）日：2010-11-04

  An object of the present invention is to provide skin external preparations and cosmetics which contain a branched acyl carnitine and have excellent formulation stability. A skin external preparation of the present invention includes a carnitine derivative represented by the following Formula (1) and/or a carnitine derivative salt represented by the following Formula (2), and an amphoteric surfactant. In Formula (1), R 1 and R 2 are each independently a C1-18 optionally branched, saturated or unsaturated aliphatic hydrocarbon group. In Formula (2), R 1 and R 2 are the same as in Formula (1), X − is a specific anion and Y + is a specific cation.

  本发明的一个目的是提供含有支链酰基肉碱并具有优异配方稳定性的皮肤外用制剂和化妆品。本发明的皮肤外用制剂包括以下式（1）所表示的肉碱衍生物和/或以下式（2）所表示的肉碱衍生物盐，以及一种两性表面活性剂。在式（1）中，R1和R2分别独立地是C1-18的可选支链、饱和或不饱和脂肪烃基。在式（2）中，R1和R2与式（1）中相同，X−是特定的阴离子，Y+是特定的阳离子。
• Cysteine derivatives
  申请人：AJINOMOTO CO., INC.

  公开号：US20020115723A1

  公开（公告）日：2002-08-22

  Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.

  本发明的目的是提供一种能够抑制细胞毒蛋白表达和基因转录调节因子激活的氧化应激抑制剂，该抑制剂在使用时具有良好的感觉和安全性；提供一种预防、延缓、缓解或治疗由氧化应激引起或促进的皮肤老化或不良美容皮肤变化的方法；提供一种含有氧化应激抑制剂作为有效成分的用于外用的化妆品组合物或皮肤科制剂。为了实现这些目的，使用一种氧化应激抑制剂，其有效成分包括至少一种来自半胱氨酸或半胱氨酸衍生物及其盐的物质。
• [EN] A SKIN CARE AND COSMETIC PREPARATION CONTAINING AN INOSITOL DERIVATIVE<br/>[FR] UNE PRÉPARATION COSMÉTIQUE ET DERMATOLOGIQUE CONTENANT UN DÉRIVÉ INOSITOL
  申请人：SHOWA DENKO KK

  公开号：WO2005092285A1

  公开（公告）日：2005-10-06

  The present invention discloses a preparation to be applied externally to the skin which contains an inositol derivative in which an inositol and a saccharide are combined. The invention aims to provide an external skin preparation that can be spread over skin without causing a granular feeling and has excellent moisturising effects and of keeping the skin healthy.

  本发明公开了一种用于外部涂抹于皮肤的制剂，其中包含一种肌醇衍生物，该肌醇衍生物中结合了肌醇和一种糖类。该发明旨在提供一种外用皮肤制剂，可以在皮肤上涂抹而不会产生颗粒感，具有优秀的保湿效果，并保持皮肤健康。
• [EN] EXTERNAL PREPARATION FOR SKIN<br/>[FR] PREPARATION EXTERNE POUR LA PEAU
  申请人：SHOWA DENKO KK

  公开号：WO2005094777A1

  公开（公告）日：2005-10-13

  The present invention provides an external preparation for skin, which comprises a multi-branched polysaccharide derivative with multi-branched polysaccharide skeleton consisting of saccharides as constituent units, wherein at least one of hydroxyl (OH) groups in the multi-branched polysaccharide skeleton is substituted by OR (wherein R represents a hydrogen atom, a hydrocarbon having 1 to 30 carbon groups or a hydrocarbon having 1 to 30 carbon groups which has hetero atom), which can give moisture and turgor to the skin, and cosmetics containing the external preparation.

  本发明提供了一种用于皮肤的外用制剂，其包括一种多支链多糖衍生物，该多支链多糖骨架由糖组成的多支链多糖骨架组成，其中多支链多糖骨架中的至少一个羟基（OH）被取代为OR（其中R代表氢原子、具有1至30个碳基团的碳氢化合物或具有1至30个碳基团的碳氢化合物，其具有杂原子），可以为皮肤提供水分和弹性，并且含有该外用制剂的化妆品。
• EMULSION PREPARATION FOR EXTERNAL APPLICATION TO SKIN AND COSMETIC PREPARATION
  申请人：Showa Denko K.K.

  公开号：EP2238970A1

  公开（公告）日：2010-10-13

  An object of the present invention is to provide emulsified skin external preparations and cosmetics which contain a branched acyl carnitine and have excellent emulsion stability. An emulsified skin external preparation according to the present invention includes 0.01 to 10% by mass of a carnitine derivative represented by the following Formula (1) and/or a carnitine derivative salt represented by the following Formula (2), and 0.01 to 20% by mass of a nonionic surfactant. In Formula (1), R1 and R2 are each independently a C1-18 optionally branched, saturated or unsaturated aliphatic hydrocarbon group. In Formula (2), R1 and R2 are the same as in Formula (1), X- is a specific anion and Y+ is a specific cation.

  本发明的一个目的是提供含有支链酰基肉碱且具有优异乳化稳定性的乳化皮肤外用制剂和化妆品。根据本发明的乳化皮肤外用制剂包括下列式（1）所表示的肉碱衍生物和/或下列式（2）所表示的肉碱衍生物盐，以及非离子表面活性剂，其质量百分含量分别为0.01至10%和0.01至20%。在式（1）中，R1和R2各自独立地是C1-18的可选支链、饱和或不饱和脂肪烃基。在式（2）中，R1和R2与式（1）中相同，X-是特定阴离子，Y+是特定阳离子。