1-(2-Chloro-7-methoxyquinolin-3-yl)ethanone | 1017463-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(2-Chloro-7-methoxyquinolin-3-yl)ethanone
• CAS: 1017463-80-7
• 化学式: C₁₂H₁₀ClNO₂
• 分子量: 235.67
• InChiKey: DOLUEKRYLFUYHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2-Chloro-7-methoxyquinolin-3-yl)ethanone 、 N-(4-methylphenyl)-2,2,2-trifluoroacetimidoyl chloride 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.5h， 以71%的产率得到8-methoxy-1-(4-methylphenyl)-2-(trifluoromethyl)benzo[b][1,8]naphthyridin-4(1H)-one
  参考文献：
  名称：

  Synthesis of 2-(trifluoromethyl)benzo[b][1,8]naphthyridin-4(1H)-one derivatives using trifluoroacetimidoyl chlorides

  摘要：

  A simple protocol is described for the synthesis of 2-(trifluoromethyl)benzo[b][1,8]naphthyridin-4(1 H)one derivatives. The reaction between diverse 2-chloro-3-acetyl-quinolines with trifluoroacetimidoyl chlorides using sodium hydride in THF at room temperature gives directly the title compounds without isolation of intermediates. Starting 2-chloro-3-acetyl-quinolines were easily prepared in two steps from readily available 2-chloro-3-formyl-quinolines. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2014.10.014
• 作为产物：
  描述：

  2-氯-7-甲氧基喹啉-3-甲醛 在 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 1-(2-Chloro-7-methoxyquinolin-3-yl)ethanone
  参考文献：
  名称：

  Synthesis of 2-(trifluoromethyl)benzo[b][1,8]naphthyridin-4(1H)-one derivatives using trifluoroacetimidoyl chlorides

  摘要：

  A simple protocol is described for the synthesis of 2-(trifluoromethyl)benzo[b][1,8]naphthyridin-4(1 H)one derivatives. The reaction between diverse 2-chloro-3-acetyl-quinolines with trifluoroacetimidoyl chlorides using sodium hydride in THF at room temperature gives directly the title compounds without isolation of intermediates. Starting 2-chloro-3-acetyl-quinolines were easily prepared in two steps from readily available 2-chloro-3-formyl-quinolines. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2014.10.014

文献信息

• AROMATIC COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
  申请人：Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

  公开号：US20200239429A1

  公开（公告）日：2020-07-30

  The invention relates to an aromatic compound, pharmaceutical composition comprising the same, and a method for preparing the compound and an intermediate thereof. The invention also relates to use of the compound for the manufacture of a medicament for the prevention or treatment of a PPAR-related disease.

  该发明涉及一种芳香化合物，包括该化合物的药物组合物，以及制备该化合物及其中间体的方法。该发明还涉及利用该化合物制备用于预防或治疗PPAR相关疾病的药物的用途。
• Aromatic compound, pharmaceutical composition and use thereof
  申请人：Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

  公开号：US11332457B2

  公开（公告）日：2022-05-17

  The invention relates to an aromatic compound, pharmaceutical composition comprising the same, and a method for preparing the compound and an intermediate thereof. The invention also relates to use of the compound for the manufacture of a medicament for the prevention or treatment of a PPAR-related disease.

  本发明涉及一种芳香族化合物、包含该化合物的药物组合物、制备该化合物及其中间体的方法。本发明还涉及使用该化合物制造预防或治疗 PPAR 相关疾病的药物。
• Synthesis of 2-(trifluoromethyl)benzo[b][1,8]naphthyridin-4(1H)-one derivatives using trifluoroacetimidoyl chlorides
  作者：Angel H. Romero、José Salazar、Simón E. López

  DOI：10.1016/j.jfluchem.2014.10.014

  日期：2015.1

  A simple protocol is described for the synthesis of 2-(trifluoromethyl)benzo[b][1,8]naphthyridin-4(1 H)one derivatives. The reaction between diverse 2-chloro-3-acetyl-quinolines with trifluoroacetimidoyl chlorides using sodium hydride in THF at room temperature gives directly the title compounds without isolation of intermediates. Starting 2-chloro-3-acetyl-quinolines were easily prepared in two steps from readily available 2-chloro-3-formyl-quinolines. (C) 2014 Elsevier B.V. All rights reserved.