alpha-[2-甲基-4-(膦酰氧基)丁基]-omega-[(2E,6E)-3,7,11-三甲基-2,6,10-十二碳三烯-1-基]聚[(2Z)-2-甲基-2-丁烯-1,4-二基] | 12698-55-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: alpha-[2-甲基-4-(膦酰氧基)丁基]-omega-[(2E,6E)-3,7,11-三甲基-2,6,10-十二碳三烯-1-基]聚[(2Z)-2-甲基-2-丁烯-1,4-二基]
• 英文名称: Dolichyl phosphate
• 英文别名: [(6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraenyl] dihydrogen phosphate
• CAS: 12698-55-4
• 化学式: C₂₅H₄₅O₄P
• 分子量: 440.6
• InChiKey: GYBNOAFGEKAZTA-QOLULZROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  30
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• TUNICAMYCIN RELATED COMPOUNDS WITH ANTI-BACTERIAL ACTIVITY
  申请人：The United States of America, as represented by the Secretary of Agriculture

  公开号：US20180208620A1

  公开（公告）日：2018-07-26

  Tunicamycin related compounds having an acyl chain double bond reduced and/or having an acyl chain double bond and an uracil ring double bond reduced are described as well as methods of making these tunicamycin related compounds. These tunicamycin related compounds are not toxic to eukaryotic cells and can be used to kill Gram-positive bacteria, alone or in combination with other antibiotics. Use of these tunicamycin related compounds to kill Gram-positive bacteria, treat Gram-positive bacterial diseases, and disinfect objects or surfaces are described. In addition, naturally-occurring streptovirudin compounds are not toxic to eukaryotic cells and can be used to kill Gram-positive bacteria, alone or in combination with other antibiotics.

  描述了具有酰基链双键减少和/或具有酰基链双键和尿嘧啶环双键减少的与吲哚霉素相关化合物，以及制备这些与吲哚霉素相关化合物的方法。这些与吲哚霉素相关的化合物对真核细胞不具有毒性，可用于单独或与其他抗生素结合来杀灭革兰氏阳性细菌。描述了使用这些与吲哚霉素相关的化合物来杀灭革兰氏阳性细菌、治疗革兰氏阳性细菌性疾病以及消毒物体或表面。此外，天然存在的链霉素类化合物对真核细胞不具有毒性，可用于单独或与其他抗生素结合来杀灭革兰氏阳性细菌。
• NOVEL IMINOSUGARS AND THEIR APPLICATIONS
  申请人：The Chancellor, Masters and Scholars of the University of Oxford

  公开号：US20130331578A1

  公开（公告）日：2013-12-12

  Iminosugar compounds are described that have inbuilt delivery features by virtue of covalent incorporation of a tocopherol moiety, or alternative moieties that are analogues of tocopherol or select analogues of cholesterol, or its antagonist “Ezitimibe”; and are likely to have broad spectrum antiviral activity. The compounds differ from previous iminosugar compounds, even lipophillic ones, being more hydrophobic and resembling fats and oils in their partition behavior in vivo into lipid phases of lipoproteins, cellular lipid droplet organelles and biological membranes. These features confer a number of unique delivery attributes in vivo, favorable to the therapy of virus infections involving cells of the lymphoid system and the liver, in particular, but these features are also favorable in general for the treatment of virus infections of man and animals.

  本文描述了一类具有内置传递特性的伊米诺糖化合物，这是由于共价结合了生育酚基团或生育酚类似物或选择性胆固醇类似物或其拮抗剂“依贝普利”而实现的，并且可能具有广谱的抗病毒活性。这些化合物与以前的伊米诺糖化合物不同，即使是亲脂性的化合物，也更具亲水性，并且在体内分配到脂蛋白、细胞脂滴器官和生物膜的脂质相中，类似于脂肪和油。这些特征在体内具有许多独特的传递属性，有利于淋巴系统和肝脏细胞感染病毒的治疗，特别是对于人和动物的病毒感染治疗也是有利的。
• Isobaric Multiplex Reagents for Carbonyl Containing Compound High-Throughput Quantitative Analysis
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20190225559A1

  公开（公告）日：2019-07-25

  The present invention provides a set of novel isobaric chemical tags, also referred herein as SUGAR (Isobaric Multiplex Reagents for Carbonyl Containing Compound). These labeling tags are compact and easy to synthesize at high yield and purity in just a few steps using commercially available starting materials. The tagging reagents of the present invention comprise: a) a reporter group, having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an aldehyde, ketone, or carboxylic acid reactive group. The multiplex SUGAR tags are able to react with an aldehyde, ketone, or carboxylic acid group of the molecule to be tagged, which offers the capability for labeling and quantitation of glycans, proteins/peptides, and fatty acids.

  本发明提供了一组新型等比化学标记，也称为SUGAR（含羰基的等比多重试剂）。这些标记标签紧凑，易于合成，使用商业可获得的起始材料，在几个步骤中高产量和纯度。本发明的标记试剂包括：a）报告者组，具有至少一个可选择同位素标记的原子；b）平衡组，也具有至少一个可选择同位素标记的原子；c）醛，酮或羧酸反应基团。多重SUGAR标记能够与待标记分子的醛，酮或羧酸基团发生反应，从而提供了对糖类，蛋白质/肽和脂肪酸进行标记和定量的能力。
• FUNCTIONALISING REAGENTS AND THEIR USES
  申请人：Watts Andrew Graham

  公开号：US20120101254A1

  公开（公告）日：2012-04-26

  Reagents and methods for functionalising polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly (alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly (alkylene glycol) molecule and/or the glycan group.

  本发明揭示了用于将多元(烷基乙二醇)分子和糖基与多肽进行官能化的试剂和方法，其基于一种官能化试剂，其包括具有乙烯基取代基的含氮杂环芳香环，其能够与自然存在或已经引入多肽中的一个或多个巯基反应，例如通过使用一个或多个半胱氨酸残基的巯基。官能化试剂与多元(烷基乙二醇)分子（例如聚乙二醇(PEG)分子）或糖基共价连接，使得多肽中的乙烯基与巯基之间的反应共价连接多肽和多元(烷基乙二醇)分子和/或糖基。
• FUNCTIONALIZING REAGENTS AND THEIR USES
  申请人：Glythera Limited

  公开号：US20140364586A1

  公开（公告）日：2014-12-11

  Reagents and methods for functionalizing polypeptides with moieties (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalizing reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalizing reagent is covalently linked to a poly(alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly(alkylene glycol) molecule and/or the glycan group.

  本文披露了一种功能化试剂和方法，用于将（烷基二醇）分子和糖基与多肽功能化。该方法基于一种功能化试剂，该试剂包含一个含氮杂环芳香环，具有一个乙烯基取代基，能够与多肽中天然存在或已引入的一个或多个巯基反应，例如使用一个或多个半胱氨酸残基的巯基。功能化试剂与多（烷基二醇）分子（例如聚乙二醇（PEG）分子）或糖基共价连接，因此，多肽中乙烯基和巯基之间的反应将多肽共价连接到多（烷基二醇）分子和/或糖基上。