3,7,19-Trimethyl-11,15-dioxa-3-azatricyclo[14.4.0.05,10]icosa-1(16),5(10),6,8,17,19-hexaene | 1031698-18-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,7,19-Trimethyl-11,15-dioxa-3-azatricyclo[14.4.0.05,10]icosa-1(16),5(10),6,8,17,19-hexaene
• CAS: 1031698-18-6
• 化学式: C₂₀H₂₅NO₂
• 分子量: 311.424
• InChiKey: HVWXMWFSNZNWIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,3-丙二醇-二-间-甲苯磺酸盐 、 2-({[(2-hydroxy-5-methylphenyl)methyl](methyl)amino}methyl)-4-methylphenol 在 氢氧化钾 作用下， 以 乙腈 为溶剂， 反应 72.0h， 以75%的产率得到3,7,19-Trimethyl-11,15-dioxa-3-azatricyclo[14.4.0.05,10]icosa-1(16),5(10),6,8,17,19-hexaene
  参考文献：
  名称：

  Synergistic effects of a specific metal template and H-bonds in controlling macrocyclization: a simple, selective, and effective cyclization from N,N-bis(2-hydroxybenzyl)alkylamine derivatives

  摘要：

  A macrocyclic compound obtained from a simple, selective, and effective reaction between N,N-bis(2-hydroxybenzyl)alkylamine derivatives and 1,3-bis(tosyloxy) propane is a good example of a cyclization controlled by synergistic effects of a metal template and hydrogen bonds. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.02.153

文献信息

• Synergistic effects of a specific metal template and H-bonds in controlling macrocyclization: a simple, selective, and effective cyclization from N,N-bis(2-hydroxybenzyl)alkylamine derivatives
  作者：Suwabun Chirachanchai、Suttinun Phongtamrug、Thitiporn Rungsimanon

  DOI：10.1016/j.tetlet.2008.02.153

  日期：2008.5

  A macrocyclic compound obtained from a simple, selective, and effective reaction between N,N-bis(2-hydroxybenzyl)alkylamine derivatives and 1,3-bis(tosyloxy) propane is a good example of a cyclization controlled by synergistic effects of a metal template and hydrogen bonds. (C) 2008 Elsevier Ltd. All rights reserved.