EX-1314 free base | 760944-56-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: EX-1314 free base
• 英文别名: [3-[(1S)-1-[(2-amino-2-methylpropanoyl)amino]-2-phenylmethoxyethyl]-[1,2,4]triazolo[4,3-a]pyridin-5-yl]methyl N-(2-amino-2-oxoethyl)-N-methylcarbamate
• CAS: 760944-56-7
• 化学式: C₂₄H₃₁N₇O₅
• 分子量: 497.5
• InChiKey: HXOYZOFSGAXBOH-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  167
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Heterocyclic aromatic compounds useful as growth hormone secretagogues
  申请人：Bristol-Myers Squibb Company

  公开号：EP2570414A1

  公开（公告）日：2013-03-20

  Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1', R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.

  所提供的新型杂环芳香族化合物可用于刺激生长激素的内源性产生或释放，所述化合物的一般结构如式 I 所示 其中 R1、R1'、R2、R3、R4、Xa、Y、Z 和 n 如本文所述。 本文提供的化合物可用于治疗肥胖症、骨质疏松症（改善骨密度）以及改善肌肉质量和肌肉力量。
• Growth-Hormone Secretagogues
  申请人：Geesaman Bard J.

  公开号：US20080261873A1

  公开（公告）日：2008-10-23

  Disclosed are methods of treating a disorder of the stomach, intestine or duodenum in a human subject. The method includes administering to the subject, a pharmaceutical composition comprising a compound that increases gastrointestinal motility (e.g., by modulating myenteric nerve activity) and/or induces the secretion or production of growth hormone.
• Heterocyclic Aromatic Compounds Useful As Growth Hormone Secretagogues
  申请人：Yu Guixue

  公开号：US20090324625A1

  公开（公告）日：2009-12-31

  Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R 1 , R 1 ′, R 2 , R 3 , R 4 , Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
• HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES
  申请人：Yu Guixue

  公开号：US20120252799A1

  公开（公告）日：2012-10-04

  Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R 1 , R 1 ′, R 2 , R 3 , R 4 , Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
• US7166596B2
  申请人：——

  公开号：US7166596B2

  公开（公告）日：2007-01-23