1R-Camphor

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1R-Camphor
• 英文别名: (4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
• 化学式: C₁₀H₁₆O
• 分子量: 152.23
• InChiKey: DSSYKIVIOFKYAU-PVSHWOEXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Oral pharmaceutical formulation for weight loss, diabetes and related disorders
  申请人：Lee Tien-Li

  公开号：US10835505B2

  公开（公告）日：2020-11-17

  There is disclosed an oral pharmaceutical formulation of bitter compounds that are agonists of taste receptor type 2 (TAS2R) receptors for the function of appetite suppression for the treatment of obesity. More specifically, the present disclosure provides an anti-obesity oral formulation comprising a bitter agent selected from the group consisting of denatonium salts including benzoate (DB), chloride (DC), acetate (DA), citrate (DCl), saccharide (DS), tartarate (DT), maleate (DM), 3-caffeoylquinic-1,5-lactone (3-CQL), chlorogenic acids (CGA), combinations thereof, and pharmaceutical excipients to facilitate a sustained release during transit through the gastrointestinal (GI) tract. Preferably, the oral pharmaceutical formulation further comprises either or both a sweet antagonist selected from the group consisting of lactisole, gymnemic acid, ziziphin, hodulcine, and combinations thereof, and a sour organic acid.

  本发明公开了一种苦味化合物的口服药物制剂，这些苦味化合物是味觉受体2型（TAS2R）受体的激动剂，具有抑制食欲的功能，可用于治疗肥胖症。更具体地说，本公开提供了一种抗肥胖口服制剂，其包含的苦味剂选自包括苯甲酸盐 (DB)、氯化物 (DC)、醋酸盐 (DA)、柠檬酸盐 (DCl)、糖苷 (DS)、酒石酸盐 (DT)、马来酸盐 (DM)、3-咖啡酰奎宁-1,5-内酯 (3-CQL)、绿原酸 (CGA)、它们的组合，以及药用辅料，以促进在胃肠道转运过程中的持续释放。优选地，口服药物制剂进一步包含选自乳异唑、钩藤碱、紫草素、霍豆碱及其组合的甜味拮抗剂和酸味有机酸中的一种或两种。
• Metal Complexes
  申请人：MERCK PATENT GMBH

  公开号：US20160233443A1

  公开（公告）日：2016-08-11

  The invention relates to metal complexes and to electronic devices, in particular organic electroluminescence devices, containing said metal complexes.
• Chemosensory Receptor Ligand-Based Therapies
  申请人：ELCELYX THERAPEUTICS, INC.

  公开号：US20170020829A1

  公开（公告）日：2017-01-26

  Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a chemosensory receptor ligand, such as a bitter receptor ligand. Also provided herein are chemosensory receptor ligand compositions, including bitter receptor ligand compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
• US9831448B2
  申请人：——

  公开号：US9831448B2

  公开（公告）日：2017-11-28
• US9962344B2
  申请人：——

  公开号：US9962344B2

  公开（公告）日：2018-05-08