Contignasterol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Contignasterol
• 英文别名: Pneumocort；(3R,4R,5R,6R,7R,8R,9S,10R,13R,14R,17R)-3,4,6,7-tetrahydroxy-17-[(1S)-1-[(2S,4S)-6-hydroxy-4-propan-2-yloxan-2-yl]ethyl]-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,16,17-tetradecahydrocyclopenta[a]phenanthren-15-one
• 化学式: C₂₉H₄₈O₇
• 分子量: 508.696
• InChiKey: IRHVLQMEQPABHG-ZLYSWTFPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  36
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Use of loteprednol etabonate for the treatment of dry eye
  申请人：BAUSCH & LOMB INCORPORATED

  公开号：EP2127655A1

  公开（公告）日：2009-12-02

  Disclosed in embodiments herein is a method of treating chronic dry eye in a patient in need thereof, the method comprising topically administering to the patient Loteprednol etabonate in an ophthalmolically acceptable carrier.

  本文实施例中公开了一种治疗有需要的患者慢性干眼症的方法，该方法包括向患者局部施用眼科可接受载体中的洛泼尼醇酯。
• Method for treating dry eye disorders
  申请人：Alcon, Inc.

  公开号：US20030008853A1

  公开（公告）日：2003-01-09

  22,29-epoxy-3,4,6,7,29-pentahydroxy-,(3&agr;,4&bgr;,5&agr;,6&agr;,7&bgr;,14&bgr;,22S)-stigmastan-15-one is useful for treating dry eye disorders and other disorders requiring the wetting of the eye.

  22,29-环氧-3,4,6,7,29-五羟基-(3&agr;,4&bgr;,5&agr;,6&agr;,7&bgr;,14&bgr;,22S)-司地卡司坦-15-酮可用于治疗干眼症和其他需要湿润眼球的疾病。
• METHOD OF TREATING DRY EYE DISORDERS
  申请人：Alcon, Inc.

  公开号：EP1392322A1

  公开（公告）日：2004-03-03
• USE OF LOTEPREDNOL ETABONATE FOR THE TREATMENT OF DRY EYE
  申请人：BAUSCH & LOMB INCORPORATED

  公开号：EP1744759A2

  公开（公告）日：2007-01-24
• Use of Loteprednol etabonate for the treatment of dry eye
  申请人：Meyering J. Robert

  公开号：US20050182039A1

  公开（公告）日：2005-08-18

  Disclosed in embodiments herein is a method of treating dry eye in a patient in need thereof, the method comprising topically administering to the patient Loteprednol etabonate in an ophthalmolically acceptable carrier.