ixerin D | 93236-44-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: ixerin D
• 英文别名: Ftidkiazunxncj-wbyqcalvsa-；(3aS,6R,6aR,8S,9aR,9bS)-6-hydroxy-6-methyl-3,9-dimethylidene-8-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one
• CAS: 93236-44-3
• 化学式: C₂₁H₃₀O₉
• 分子量: 426.464
• InChiKey: FTIDKIAZUNXNCJ-WBYQCALVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  ixerin D 在 吡啶 、 三氯氧磷 作用下， 反应 4.5h， 生成 glucozaluzanin C tetraacetate
  参考文献：
  名称：

  Sesquiterpene lactones from Ixeris tamagawaensis Kitam. II.

  摘要：

  从玉川龙葵（lxeris tamagawaensis KITAM）的极性馏分中分离出了三种新的愈创木内酯葡萄糖苷（ixerins D、E 和 F）和一种新的美兰珀内酯葡萄糖苷（ixerin G）。根据光谱数据和几种化学变化，阐明了它们的结构。

  DOI：

  10.1248/cpb.32.3036
• 作为产物：
  描述：

  prenantheside B 在 sodium hydroxide 作用下， 反应 1.0h， 生成 ixerin D
  参考文献：
  名称：

  Miyase, Toshio; Yamada, Mayumi; Fukushima, Seigo, Chemical and pharmaceutical bulletin, 1987, vol. 35, # 5, p. 1969 - 1974

  摘要：

  DOI：

文献信息

• Sesquiterpene lactones from Ixeris dentata Nakai.
  作者：MAMORU SETO、TOSHIO MIYASE、SEIGO FUKUSHIMA

  DOI：10.1248/cpb.34.4170

  日期：——

  Three new sesquiterpene glycosides, ixerin U (III), ixerin V (IV), and ixerin W (XI), in addition to eight known sesquiterpenes, have been isolated from Ixeris dentata NAKAI. The structures of the new compounds were determined on the basis of chemical and spectral data.

  除了八种已知的倍半萜外，还从 Ixeris dentata NAKAI 中分离出三种新的倍半萜糖苷：ixerin U (III)、ixerin V (IV) 和 ixerin W (XI)。新化合物的结构是根据化学和光谱数据确定的。
• Medicament containing taraxacum plant root extract for treatment or prevention of cancer, and method for preparing same
  申请人：Pandey Siyaram

  公开号：US10179156B2

  公开（公告）日：2019-01-15

  The present invention relates to an improved method for preparing a medicament comprising a Taraxacum plant root extract for the treatment or prevention of a cancer. In one aspect, the method comprises freezing Taraxacum plant root to obtain a frozen root stock, said freezing step being selected to effect at least partial disruption of one or more root cells; dry grinding the frozen root stock to obtain a ground root powder, wherein during said dry grinding step the frozen root stock is maintained at a grinding temperature below about 40° C.; steeping the ground root powder with a solvent to obtain a suspension having a liquid extract portion and a solid particle portion; and separating the liquid extract portion from the solid particle portion to provide a separated liquid extract for use in the medicament.

  本发明涉及一种改进的方法，用于制备包含蒲公英植物根提取物的药物，以治疗或预防癌症。在一个方面中，该方法包括冷冻蒲公英植物根以获得冷冻根浆，所述冷冻步骤被选择用于至少部分破坏一个或多个根细胞；干磨冷冻根浆以获得研磨根粉，其中在所述干磨步骤中，冷冻根浆保持在低于约 40°C 的研磨温度下；用溶剂浸泡研磨根粉以获得具有液体提取物部分和固体颗粒部分的悬浮液；以及从固体颗粒部分分离液体提取物部分以提供用于药剂的分离液体提取物。
• MEDICAMENT CONTAINING TARAXACUM PLANT ROOT EXTRACT FOR TREATMENT OR PREVENTION OF CANCER, AND METHOD FOR PREPARING SAME
  申请人：University of Windsor

  公开号：EP2817017A1

  公开（公告）日：2014-12-31
• Medicament Containing Taraxacum Plant Root Extract for Treatment or Prevention of Cancer, and Method for Preparing Same
  申请人：Pandey Siyaram

  公开号：US20150010665A1

  公开（公告）日：2015-01-08

  The present invention relates to an improved method for preparing a medicament comprising a Taraxacum plant root extract for the treatment or prevention of a cancer. In one aspect, the method comprises freezing Taraxacum plant root to obtain a frozen root stock, said freezing step being selected to effect at least partial disruption of one or more root cells; dry grinding the frozen root stock to obtain a ground root powder, wherein during said dry grinding step the frozen root stock is maintained at a grinding temperature below about 40° C.; steeping the ground root powder with a solvent to obtain a suspension having a liquid extract portion and a solid particle portion; and separating the liquid extract portion from the solid particle portion to provide a separated liquid extract for use in the medicament.
• [EN] MEDICAMENT CONTAINING TARAXACUM PLANT ROOT EXTRACT FOR TREATMENT OR PREVENTION OF CANCER, AND METHOD FOR PREPARING SAME<br/>[FR] MÉDICAMENT CONTENANT DE L'EXTRAIT DE RACINE DE TARAXACUM POUR LE TRAITEMENT OU LA PRÉVENTION DU CANCER, ET SA MÉTHODE DE PRÉPARATION
  申请人：UNIV WINDSOR

  公开号：WO2013116936A1

  公开（公告）日：2013-08-15

  The present invention relates to an improved method for preparing a medicament comprising a Taraxacum plant root extract for the treatment or prevention of a cancer. In one aspect, the method comprises freezing Taraxacum plant root to obtain a frozen root stock, said freezing step being selected to effect at least partial disruption of one or more root cells; dry grinding the frozen root stock to obtain a ground root powder, wherein during said dry grinding step the frozen root stock is maintained at a grinding temperature below about 40°C; steeping the ground root powder with a solvent to obtain a suspension having a liquid extract portion and a solid particle portion; and separating the liquid extract portion from the solid particle portion to provide a separated liquid extract for use in the medicament.