β-D-果糖基葡萄糖1-氨基磺酸盐 | 106881-42-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: β-D-果糖基葡萄糖1-氨基磺酸盐
• 英文名称: beta-D-Fructopyranose 1-Sulfamate
• 英文别名: [(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methyl sulfamate
• CAS: 106881-42-9
• 化学式: C₆H₁₃NO₈S
• 分子量: 259.24
• InChiKey: BGTCZSJLWAMWRH-ARQDHWQXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  168
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Use of sulfamate derivatives for treating impulse control disorders
  申请人：——

  公开号：US20010023254A1

  公开（公告）日：2001-09-20

  Impulse Control Disorders (ICD's) are characterized by harmful behaviors performed in response to irresistible impulses. The essential feature of an ICD is the failure to resist an impulse, drive, or temptation and to perform an act that is harmful to the person or to others. The present invention comprises methods for the treatment or prevention of ICD's using a class of sulfamates of the following formula: 1 wherein X is CH 2 or oxygen, and R 1 , R 2 , R 3 , R4 and R 5 are as herein defined. Further, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and intermediates form part of the present invention are also disclosed.

  冲动控制障碍(ICD)的特征为在无法抵制的冲动下进行有害行为。ICD的本质特征是无法抵制冲动、驱动力或诱惑，并执行对个人或他人有害的行为。本发明涉及使用以下公式的磺酰胺类治疗或预防ICD的方法：1其中X为CH2或氧，R1、R2、R3、R4和R5如本文所定义。此外，本发明还揭示了含有公式(I)化合物的制药组合物以及其使用方法和中间体。
• USE OF SULFAMATE DERIVATIVES FOR TREATING IMPULSE CONTROL DISORDERS
  申请人：UNIVERSITY OF CINCINNATI

  公开号：EP1158973A2

  公开（公告）日：2001-12-05
• EP1414437A2
  申请人：——

  公开号：EP1414437A2

  公开（公告）日：2004-05-06
• TOPIRAMATE COMPOSITIONS FOR TREATMENT OF HEADACHE
  申请人：Hendrix, Curt

  公开号：EP1922066A2

  公开（公告）日：2008-05-21
• [EN] USE OF SULFAMATE DERIVATIVES FOR TREATING IMPULSE CONTROL DISORDERS<br/>[FR] TRAITEMENT DES TROUBLES DU CONTROLE DES IMPULSIONS A BASE DE DERIVES SULFAMATES
  申请人：UNIV CINCINNATI

  公开号：WO2000050020A2

  公开（公告）日：2000-08-31

  Impulse Control Disorders (ICDs) are characterized by harmful behaviors performed in response to irresistible impulses. The essential feature of an ICD is the failure to resist an impulse, drive, or temptation and to perform an act that is harmful to the person or to others. The present invention comprises methods for the treatment or prevention of ICDs using a class of sulfamates of formula (I) wherein X is CH2 or oxygen, and R1, R2, R3, R4 and R5 are as herein defined. Further, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and intermediates form part of the present invention are also disclosed.