2'-amino-4-bromo-1'-(4-methoxyphenyl)-7',7'-dimethyl-2,5'-dioxo-5',6',7',8'-tetrahydro-1'H-spiro[indoline-3,4'-quinoline]-3'-carbonitrile | 1146746-58-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2'-amino-4-bromo-1'-(4-methoxyphenyl)-7',7'-dimethyl-2,5'-dioxo-5',6',7',8'-tetrahydro-1'H-spiro[indoline-3,4'-quinoline]-3'-carbonitrile
• 英文别名: 2'-amino-4-bromo-1'-(4-methoxyphenyl)-7',7'-dimethyl-2,5'-dioxospiro[1H-indole-3,4'-6,8-dihydroquinoline]-3'-carbonitrile
• CAS: 1146746-58-8
• 化学式: C₂₆H₂₃BrN₄O₃
• 分子量: 519.398
• InChiKey: YVIOKTKLTAESHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  34
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-溴靛红 、 3-[(4-甲氧苯基)氨基]-5,5-二甲基-1-环己-2-烯酮 、 丙二腈 以 乙醇 为溶剂， 反应 0.17h， 以67%的产率得到2'-amino-4-bromo-1'-(4-methoxyphenyl)-7',7'-dimethyl-2,5'-dioxo-5',6',7',8'-tetrahydro-1'H-spiro[indoline-3,4'-quinoline]-3'-carbonitrile
  参考文献：
  名称：

  Microwave-Assisted Synthesis of New Spiro[indoline-3,4′-quinoline] Derivatives via a One-Pot Multicomponent Reaction

  摘要：

  A simple and efficient synthesis of spiro[indoline-3,4'-quinoline] derivatives by a one-pot reaction of isatin, malononitrile, and enaminone under microwave irradiation was investigated. This protocol has the advantages of short reaction time, high yields of products, broad substrate scope, and easy workup procedure.

  DOI：

  10.1080/00397910802527714

文献信息

• Microwave-Assisted Synthesis of New Spiro[indoline-3,4′-quinoline] Derivatives via a One-Pot Multicomponent Reaction
  作者：Song-Lei Zhu、Kai Zhao、Xiao-Ming Su、Shun-Jun Ji

  DOI：10.1080/00397910802527714

  日期：2009.3.25

  A simple and efficient synthesis of spiro[indoline-3,4'-quinoline] derivatives by a one-pot reaction of isatin, malononitrile, and enaminone under microwave irradiation was investigated. This protocol has the advantages of short reaction time, high yields of products, broad substrate scope, and easy workup procedure.