2-[(7-Methoxy-4-methyl-quinolin-2-yl)-hydrazono]-propionic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[(7-Methoxy-4-methyl-quinolin-2-yl)-hydrazono]-propionic acid
• 英文别名: (2E)-2-[(7-methoxy-4-methylquinolin-2-yl)hydrazinylidene]propanoic acid
• 化学式: C₁₄H₁₅N₃O₃
• 分子量: 273.291
• InChiKey: ARLFEURYGHUBDC-CXUHLZMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丙酮酸 、 2-肼基-7-甲氧基-4-甲基喹啉 反应 2.0h， 生成 2-[(7-Methoxy-4-methyl-quinolin-2-yl)-hydrazono]-propionic acid
  参考文献：
  名称：

  Chelating agents as potential antitumorals. 2-quinolylhydrazones and bis-2-quinolylhydrazones. I

  摘要：

  A number of pyruvic acid, methylpyruvate and pyruvic carboxaldehyde 2-quinolylhydrazones have been synthesized. Some bis-2-quinolylhydrazones were also obtained during the reaction with pyruvic carboxaldehyde. All these compounds have been evaluated for cytotoxicity and most display a significant in vitro activity against a variety of cell lines.

  DOI：

  10.1016/0223-5234(96)88268-7

文献信息

• Chelating agents as potential antitumorals. 2-quinolylhydrazones and bis-2-quinolylhydrazones. I
  作者：L Savini、P Massarelli、L Chiasserini、A Sega、C Pellerano、A Barzi、G Nocentini

  DOI：10.1016/0223-5234(96)88268-7

  日期：1995.1

  A number of pyruvic acid, methylpyruvate and pyruvic carboxaldehyde 2-quinolylhydrazones have been synthesized. Some bis-2-quinolylhydrazones were also obtained during the reaction with pyruvic carboxaldehyde. All these compounds have been evaluated for cytotoxicity and most display a significant in vitro activity against a variety of cell lines.