3-amino-4-isobutylamino-1H-pyrazolo[4,3-c]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-amino-4-isobutylamino-1H-pyrazolo[4,3-c]quinoline
• 英文别名: 4-N-(2-methylpropyl)-1H-pyrazolo[4,3-c]quinoline-3,4-diamine
• 化学式: C₁₄H₁₇N₅
• 分子量: 255.322
• InChiKey: AYEGYZXVVPLTMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  79.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-二氯喹啉-3-甲腈 在 一水合肼 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 96.0h， 生成 3-amino-4-isobutylamino-1H-pyrazolo[4,3-c]quinoline
  参考文献：
  名称：

  FUSED QUINOLINE HETEROCYCLES. II. FIRST SYNTHESIS OF 1,2,3,4,5,6-HEXAAZAACEANTHRYLENES AND 5,7,8,10a,11-PENTAAZABENZO[a]-FLUORENES

  摘要：

  The new tetracyclic ring systems 5-alkyl-1,5-dihydro-1,2,3,4,5,6-hexaazaaceanthrylenes 5a-d were synthesized by diazotization of 4-alkylamino-3-amino-1H-pyrazolo[4,3-c]quinolines 4a-d. The 4-arylamino-3-diazo-1H-pyrazolo-[4,3-c]-quinolines 6e-h, which were prepared by diazotisation of the corresponding amines 4e-h, readily formed the novel tetracyclic ring system ethyl 6-arylamion-10-methyl-5,7,8,10a,11-pentaazabenzo[a]fluorene-9-carboxylates 8e-h, when treated with ethyl acetoacetate.

  DOI：

  10.1081/scc-100104413

文献信息

• FUSED QUINOLINE HETEROCYCLES. II. FIRST SYNTHESIS OF 1,2,3,4,5,6-HEXAAZAACEANTHRYLENES AND 5,7,8,10a,11-PENTAAZABENZO[a]-FLUORENES
  作者：Ramadan Ahmed Mekheimer

  DOI：10.1081/scc-100104413

  日期：2001.1

  The new tetracyclic ring systems 5-alkyl-1,5-dihydro-1,2,3,4,5,6-hexaazaaceanthrylenes 5a-d were synthesized by diazotization of 4-alkylamino-3-amino-1H-pyrazolo[4,3-c]quinolines 4a-d. The 4-arylamino-3-diazo-1H-pyrazolo-[4,3-c]-quinolines 6e-h, which were prepared by diazotisation of the corresponding amines 4e-h, readily formed the novel tetracyclic ring system ethyl 6-arylamion-10-methyl-5,7,8,10a,11-pentaazabenzo[a]fluorene-9-carboxylates 8e-h, when treated with ethyl acetoacetate.