豆甾醇 | 68555-08-8

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物 - 环醇
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 豆甾醇
• 英文名称: 17-(4-Ethyl-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• 英文别名: 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol；β-sitosterol；β-steriod；sitosterol；stigmast-5-en-3β-ol；24-Ethyl-22-dihydroporiferasterol
• CAS: 68555-08-8
• 化学式: C₂₉H₅₀O
• mdl: MFCD00066862
• 分子量: 414.715
• InChiKey: KZJWDPNRJALLNS-UHFFFAOYSA-N

物化性质

• 熔点：
  165-167 °C(lit.)
• 溶解度：
  几乎不溶于水，溶于四氢呋喃，微溶于乙酸乙酯。

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3
• 海关编码：
  2906199090

制备方法与用途

豆甾醇是一种天然产物，广泛应用于实验室研发和化工生产中。它主要用于合成甾体激素的原料，并可作为维生素D3的生产原料。

文献信息

• Processes for preparations of 9,11-epoxy steroids and intermediates useful therein
  申请人：Ng S. John

  公开号：US20080027237A1

  公开（公告）日：2008-01-31

  Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of 9,11-epoxy steroids.

  为合成9,11-环氧类固醇提供了多种新的反应方案、新的工艺步骤和新的中间体。
• CHOLESTERIC LIQUID CRYSTAL COMPOSITION
  申请人：TANABE MAYUMI

  公开号：US20100086506A1

  公开（公告）日：2010-04-08

  A cholesteric liquid crystal composition containing at least one esterified product selected from the group consisting of (1) an esterified product of a hydrolysate of (A) a γ-oryzanol and (B1) a carboxylic acid compound, (2) an esterified product of a hydrogenated product of a hydrolysate of (A) a γ-oryzanol and (B2) a carboxylic acid compound, and (3) an esterified product of a hydrogenated product of (A) a γ-oryzanol and (B3) a carboxylic acid compound. The γ-oryzanol (A) is a mixture containing at least one ferulate ester of a vegetable sterol and at least one ferulate ester of a triterpene alcohol, and the hydrolysate of the γ-oryzanol (A) is a mixture containing at least one vegetable sterol and at least one triterpene alcohol.

  一种胆甾烷液晶组合物，包含至少一种酯化产物，所述酯化产物选自以下组合物：（1）（A）γ-谷维素和（B1）羧酸化合物的水解产物的酯化产物，（2）（A）γ-谷维素的氢化产物和（B2）羧酸化合物的水解产物的酯化产物，以及（3）（A）γ-谷维素的氢化产物和（B3）羧酸化合物的酯化产物。γ-谷维素（A）是一种混合物，包含至少一种植物固醇的酰基杂酯和至少一种三萜醇的酰基杂酯，γ-谷维素（A）的水解产物是一种混合物，包含至少一种植物固醇和至少一种三萜醇。
• Pharmaceutical Composition Suitable for Use in a Dry Powder Inhaler
  申请人：Nyambura Bildad Kimani

  公开号：US20130177651A1

  公开（公告）日：2013-07-11

  This invention relates to a pharmaceutical composition suitable for use in a dry powder inhaler comprising: (i) carrier particles; (ii) active particles on the surface of the carrier particles; and (iii) excipient on the surface of the carrier particles, wherein the excipient comprises phytosterol, phytosterol derivative, phytostanol, phytostanol derivative or combinations thereof. This invention relates to a method of applying the excipient particles onto the carrier particles.

  本发明涉及一种适用于干粉吸入器的制药组合物，包括：（i）载体颗粒；（ii）活性颗粒位于载体颗粒表面；（iii）赋形剂位于载体颗粒表面，其中赋形剂包括植物固醇、植物固醇衍生物、植物甾醇、植物甾醇衍生物或其组合物。本发明还涉及将赋形剂颗粒应用于载体颗粒的方法。
• ISOLATED AQUEOUS ENZYMATIC PREPARATION AND THE USE THEREOF FOR THE FUNCTIONALIZATION OF THE SURFACE OF PAPER OR CELLULOSIC SUBSTRATES
  申请人：Universitat Politècnica De Catalunya

  公开号：EP2857504A1

  公开（公告）日：2015-04-08

  In a first aspect, the present invention relates to an isolated aqueous enzymatic preparation obtained from the reaction of at least one oxidoreductase enzyme, preferably a laccase, and at least one natural or synthetic product, preferably a natural compound, said natural or synthetic product comprising, in the structure thereof, at least one phenol or alcohol group, which optionally has one or more hydrophobic chains, or at least one sterol group. In a second aspect, the present invention relates to the use of said isolated aqueous enzymatic preparation in the functionalization of the surface of paper or cellulosic substrates.

  第一方面，本发明涉及一种分离的水性酶制剂，由至少一种氧化还原酶（最好是漆酶）和至少一种天然或合成产物（最好是天然化合物）反应而得，所述天然或合成产物在其结构中包含至少一个酚或醇基团（可选择具有一个或多个疏水链）或至少一个甾醇基团。第二方面，本发明涉及将所述分离的水性酶制剂用于纸张或纤维素基质表面的功能化。
• Oil composition, production method thereof, oily base and external preparation for skin
  申请人：YOKOZEKI OIL & FAT INDUSTRIES CO., LTD.

  公开号：US10945939B2

  公开（公告）日：2021-03-16

  An oil composition containing 70 to 100% by mass of an oil composition (A) which is mainly composed of a steradiene having a 3, 5-conjugated diene structure formed by dehydrating a hydroxyl group at 3-C of phytosterol, while having a phytosterol content of 20% by mass or less, and which is liquid at 25° C., and 0 to 30% by mass of an oil (B) which is soluble in the oil composition (A) has excellent transparency and gloss imparting property, and is useful as an oily base to produce an external preparation for skin. An external preparation for skin which contains the oil composition as an oil base is excellent in gloss and adhesion. The content of the steradiene in the oil composition (A) is usually 60% by mass or more, and is preferably 95% by mass or more.

  一种油类组合物含有 70% 至 100% 质量的油类组合物 (A)，该组合物主要由具有 3，5-共轭二烯结构的甾二烯组成，该结构由植物甾醇 3-C 处的羟基脱水形成，同时植物甾醇含量不超过 20% （以质量计），且在 25°C 时为液态；以及 0% 至 30% 质量的油类 (B)，该油类可溶于油类组合物 (A)、以及 0-30% 质量分数的油 (B)，该油可溶于油组合物 (A)，具有极佳的透明度和光泽度，可用作生产皮肤外用制剂的油基。含有该油组合物作为油基的皮肤外用制剂具有极佳的光泽度和附着力。油组合物（A）中的甾二烯含量通常为 60% 或更高，最好为 95% 或更高。