丙酰肉碱盐酸盐 | 119793-66-7

• 物质功能分类: 生物化工 - 生化试剂 - 激动剂抑制剂
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 丙酰肉碱盐酸盐
• 中文别名: 丙酰右旋肉碱盐酸盐；(R)-2-丙酰氧基-3-羧基-N,N,N-三甲基丙铵氯化物；丙酰左旋肉碱盐酸盐；丙酰L(-)-肉碱盐酸盐；盐酸丙酰左卡尼汀；丙酰L-肉碱盐酸盐；丙酰左旋肉碱
• 英文名称: propionyl-L-carnitine hydrochloride
• 英文别名: levocarnitine propionate hydrochloride；(R)-3-(Propionyloxy)-4-(trimethylammonio)butanoate hydrochloride；(3R)-3-propanoyloxy-4-(trimethylazaniumyl)butanoate;hydrochloride
• CAS: 119793-66-7
• 化学式: C₁₀H₂₀NO₄*Cl
• 分子量: 253.726
• InChiKey: KTFMPDDJYRFWQE-DDWIOCJRSA-N

物化性质

• 熔点：
  165-167°C
• 溶解度：
  可溶于氯仿（少许）、水（少许）
• 碰撞截面：
  146.8 Ų [M]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

计算性质

• 辛醇/水分配系数(LogP)：
  -2.51
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2923900090
• 危险性防范说明：
  P264,P280,P302+P352+P332+P313+P362+P364,P305+P351+P338+P337+P313
• 危险性描述：
  H315,H319
• 储存条件：
  Store at 0°C

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Propionyl-L-carnitine, HCl
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Propionyl-L-carnitine, HCl
CAS number: 119793-66-7

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C10H20NO4.Cl
Molecular weight: 253.7

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途

丙酰肉碱盐酸盐为白色或结晶性粉末，主要用于治疗肾功能恶化和充血性心力衰竭等疾病。

生物活性

L-丙酰肉碱盐酸盐（Levocarnitine propionate hydrochloride）用于研究肾功能恶化、充血性心脏衰竭及间歇性跛行等症状。

化学性质

丙酰左旋肉碱盐酸盐是左旋肉碱的酯化物，不易吸潮，为白色粉末，易溶于水，但难溶于丙酮和乙醚。

反应信息

• 作为反应物：
  描述：

  丙酰肉碱盐酸盐 在 草酰氯 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of Carnitine Benzyl Esters as Prodrugs

  摘要：

  在左旋肉碱中引入 C-2酰基和苄基酯后，产生了一系列左旋肉碱苄基酯原药，它们的脂溶性、稳定性和生物利用度都得到了改善。

  DOI：

  10.3184/030823408x324689
• 作为产物：
  描述：

  丙酰氯 、 左旋肉碱盐酸盐 在 三氟乙酸 作用下， 反应 20.0h， 生成 丙酰肉碱盐酸盐
  参考文献：
  名称：

  Synthesis of Carnitine Benzyl Esters as Prodrugs

  摘要：

  在左旋肉碱中引入 C-2酰基和苄基酯后，产生了一系列左旋肉碱苄基酯原药，它们的脂溶性、稳定性和生物利用度都得到了改善。

  DOI：

  10.3184/030823408x324689

文献信息

• [EN] L-CARNITINE AND ALKANOYL L-CARNITINE PHYTATES AND PROCESS FOR PREPARING THE SAME<br/>[FR] PHYTATES DE L-CARNITINE ET D'ALCANOYLE L-CARNITINE, ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：SCIAN LAB LLC

  公开号：WO2010005465A1

  公开（公告）日：2010-01-14

  Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1 :1 to 6:1, wherein: n = 1-6; R1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.

  L-肉碱盐和烷酰基L-肉碱盐与一般公式(I)的植酸，以及制备这些化合物的过程，其中L-肉碱或其烷酰衍生物阳离子与植酸阴离子之间的摩尔比在1:1至6:1的范围内，其中：n = 1-6；R1为植酸阴离子；R为氢、具有2-12个碳原子的直链烷酰基团或具有2-12个碳原子的支链烷酰基团。
• L-carnitine and alkanoyl L-carnitine phytates and process for preparing the same
  申请人：Chen Jian

  公开号：US20100317890A1

  公开（公告）日：2010-12-16

  Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1:1 to 6:1, wherein: n=1-6; R 1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.

  L-肉碱盐和辛酰基L-肉碱盐与通式(I)的植酸，以及其制备方法，其中L-肉碱或其辛酰基衍生物阳离子与植酸阴离子之间的摩尔比在1:1至6:1的范围内，其中：n=1-6；R1是植酸阴离子；R是氢，具有2-12个碳原子的直链辛酰基或具有2-12个碳原子的支链辛酰基。
• 一种合成甘氨酸丙酰左旋肉碱盐酸盐的方法
  申请人：辽宁科硕营养科技股份有限公司

  公开号：CN107325013B

  公开（公告）日：2019-04-12

  本发明实施例公开了一种合成甘氨酸丙酰左旋肉碱盐酸盐的方法，以不易吸潮的丙酰左旋肉碱盐酸盐和甘氨酸为原料，两种原料以一定摩尔比，用单一无机溶剂如C1‑C6醇依次溶解，于50‑100℃加热反应0.5‑5小时后，降温、析晶、分离得到所析出的晶体，即得甘氨酸丙酰左旋肉碱盐酸盐。本发明提供的方法，不需要真空浓缩，减少操作步骤，用时短，提高了生产效率，同时也降低了能耗；采用单一溶剂C1‑C6醇，便于溶剂回收再利用，大大的减少了溶剂的浪费，节约了成本，而且C1‑C6醇对环保的危害要远远小于丙酮；所得产品质量合格，收率可以达到95％以上，最高可达98％以上，适合工业化大生产。
• Use of L-Carnitine, salts and derivatives thereof for reducing or preventing fatigue and improving cognitive function
  申请人：Lonza Ltd

  公开号：EP2508179A1

  公开（公告）日：2012-10-10

  The invention relates to the use of L-carnitine, a salt of L-carnitine, a derivative of L-carnitine and/or salt of a derivative of L-carnitine, as well as respective methods and compositions, for reducing or preventing fatigue and/or for improving cognitive function in an animal. The animal is preferably a healthy individual and the use is preferably a non-therapeutic use.

  本发明涉及使用左旋肉碱、左旋肉碱盐、左旋肉碱衍生物和/或左旋肉碱衍生物盐，以及相应的方法和组合物，用于减轻或预防动物的疲劳和/或改善认知功能。该动物最好是健康个体，使用最好是非治疗性使用。
• SALTS OF CARNITINE DERIVATIVES AND METHODS OF PRODUCTION
  申请人：ThermoLife International, LLC

  公开号：US20150166466A1

  公开（公告）日：2015-06-18

  Disclosed are salts, such as nitrates, of acetyl-L-carnitine and propionyl-L-carnitine and methods of making the compounds.

  本发明涉及乙酰-L-肉碱和丙酰-L-肉碱的盐，如硝酸盐，以及制备这些化合物的方法。