3-methyl-3,5-diphenyl-2-[(trimethylsilyl)oxy]-1-pentene

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 3-methyl-3,5-diphenyl-2-[(trimethylsilyl)oxy]-1-pentene
• 英文别名: Trimethyl-(3-methyl-3,5-diphenylpent-1-en-2-yl)oxysilane；trimethyl-(3-methyl-3,5-diphenylpent-1-en-2-yl)oxysilane
• 化学式: C₂₁H₂₈OSi
• 分子量: 324.538
• InChiKey: BPVLPTSZPLMFDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.94
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  三甲基氯硅烷 、 甲苯 、 噁丁环,3-甲基-2-亚甲基-3-苯基- 在 正丁基锂 、 四甲基乙二胺 作用下， 以 正己烷 为溶剂， 反应 2.05h， 以100%的产率得到3-methyl-3,5-diphenyl-2-[(trimethylsilyl)oxy]-1-pentene
  参考文献：
  名称：

  Ring opening reactions of 2-methyleneoxetanes

  摘要：

  Ring opening of 2-methyleneoxetanes with stabilized carbanion nucleophiles provides substituted ketones. The intermediate enolate can be trapped as its silylenol ether. If the 2-methyleneoxetane is exposed to more strongly basic carbanions, the corresponding homopropargylic alcohol is isolated in excellent yield. A variety of heteroatom nucleophiles also open the 2-methyleneoxetane in good to excellent yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00724-x

文献信息

• Ring opening reactions of 2-methyleneoxetanes
  作者：Ying Wang、Henri Bekolo、Amy R. Howell

  DOI：10.1016/s0040-4020(02)00724-x

  日期：2002.8

  Ring opening of 2-methyleneoxetanes with stabilized carbanion nucleophiles provides substituted ketones. The intermediate enolate can be trapped as its silylenol ether. If the 2-methyleneoxetane is exposed to more strongly basic carbanions, the corresponding homopropargylic alcohol is isolated in excellent yield. A variety of heteroatom nucleophiles also open the 2-methyleneoxetane in good to excellent yields. (C) 2002 Elsevier Science Ltd. All rights reserved.