2-deoxy-2-fluoro-5-carboxy-β-D-arabinofuranosyl-6-methoxyadenine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-deoxy-2-fluoro-5-carboxy-β-D-arabinofuranosyl-6-methoxyadenine
• 英文别名: (2R,3R,5R)-4-fluoro-2-(hydroxymethyl)-5-(6-methoxypurin-9-yl)oxolan-3-ol
• 化学式: C₁₁H₁₃FN₄O₄
• 分子量: 284.247
• InChiKey: BQLCZDLJTPAFTK-RNNYNIFOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-deoxy-2-fluoro-5-carboxy-β-D-arabinofuranosyl-6-methoxyadenine 在 platinum on activated charcoal 氢气 、 碳酸氢钠 作用下， 以 水 为溶剂， 反应 0.5h， 生成 2-deoxy-2-fluoro-5-carboxy-β-D-arabinofuranosyl-6-methoxyadenine
  参考文献：
  名称：

  [EN] NUCLEOSIDE PHOSPHONATE CONJUGATES AS ANTI HIV AGENTS
  [FR] COMPOSÉS ANTIVIRAUX

  摘要：

  公开号：

  WO2006015261A3
• 作为产物：
  描述：

  2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl-9H-6-chloropurine 、 sodium methylate 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以88%的产率得到2-deoxy-2-fluoro-5-carboxy-β-D-arabinofuranosyl-6-methoxyadenine
  参考文献：
  名称：

  [EN] NUCLEOSIDE PHOSPHONATE CONJUGATES AS ANTI HIV AGENTS
  [FR] COMPOSÉS ANTIVIRAUX

  摘要：

  公开号：

  WO2006015261A3

文献信息

• Antiviral Compounds
  申请人：Boojamra Constantine G.

  公开号：US20090012037A1

  公开（公告）日：2009-01-08

  The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗病毒抑制化合物、含有这些化合物的组合物以及包括这些化合物的治疗方法，还涉及用于制备这些化合物的过程和中间体。
• Phosphonate analogs of HIV inhibitor compounds
  申请人：Boojamra G. Constantine

  公开号：US20070049754A1

  公开（公告）日：2007-03-01

  The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗病毒抑制化合物、含有该化合物的组合物、包括给予该化合物的治疗方法，以及用于制备该化合物的过程和中间体。
• ANTIVIRAL COMPOUNDS
  申请人：Gilead Sciences, Inc.

  公开号：US20140288294A1

  公开（公告）日：2014-09-25

  The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗病毒抑制化合物、含有这种化合物的组合物、包括给予这种化合物的治疗方法，以及用于制备这种化合物的过程和中间体。
• PHOSPHONATE ANALOGS OF HIV INHIBITOR COMPOUNDS
  申请人：Gilead Sciences, Inc.

  公开号：US20130090299A1

  公开（公告）日：2013-04-11

  The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗病毒抑制化合物，含有该化合物的组合物，以及包括给予该化合物的治疗方法，还涉及用于制备该化合物的过程和中间体。
• Phosphonate Analogs of Hiv Inhibitor Compounds
  申请人：Boojamra Constantine G.

  公开号：US20090202470A1

  公开（公告）日：2009-08-13

  The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  这项发明涉及磷取代的抗病毒抑制化合物、包含这些化合物的组合物和治疗方法，其中包括给予这些化合物的管理，以及用于制备这些化合物的过程和中间体。