The addition of halogens and interhalogens on palladacyclopentadienyl complexes bearing quinolyl-thioether as spectator ligands. A kinetic and computational study
in excess induces the extrusion of the di-bromo-(E, E)-σ-butadiene and the formation of the thioquinoline palladium(II) di-bromide species. The kinetics and mechanism of these reactions have been determined. Except for one case which was analyzed in detail by a computational study, the oxidative addition of the interhalogens ICl and IBr yields the species that is less predictable from the thermodynamic
COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION
申请人:Cleave Biosciences, Inc.
公开号:US20140235548A1
公开(公告)日:2014-08-21
Compounds, pharmaceutical compositions, and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by JAMM proteins are disclosed. The compounds and compositions inhibit the enzymatic activity of a JAMM domain, including the JAMM domain of the CSN5 subunit of the COP9-signalsome (CSN), the JAMM domain of the Rpn11/Poh1/Psmd14 subunit of the 26S proteasome, the JAMM domain of AMSH, the JAMM domain of AMSH-LP, the JAMM domain of BRCC36, among other JAMM domains.
Candidate compounds for specific inhibition of Rpn11 are represented by Formula 1a
where each of R2, R3, R4, R5, R6, and R7 is independently selected from hydrogen (H), substituted and unsubstituted alkyl groups, carboxyl groups, or substituted and unsubstituted carboxyamides.
Candidate compounds for specific inhibition of Rpn11 are represented by Formula 1a
where each of R
2
, R
3
, R
4
, R
5
, R
6
, and R
7
is independently selected from hydrogen (H), substituted and unsubstituted alkyl groups, carboxyl groups, or substituted and unsubstituted carboxyamides.
Synthesis and reactivity toward olefin exchange and oxidative addition of some platinum(0) olefin complexes with thioquinolines as spectator ligands
elemental analysis sixteen Pt(0) derivatives stabilized by four different thioquinoline spectator ligands and four different deactivated olefins. Moreover we have studied the reactivity and proposed a mechanism for olefin-olefin, olefin-alkyne exchange and oxidative addition of alkyl halides to this new class of Pt(0) derivatives based on detailed kinetic measurements. The kinetic study was carried out by