arteannuin B

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: arteannuin B
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: QWQSMEDUZQDVLA-MDVCWSJWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.45
• 重原子数：
  18.0
• 可旋转键数：
  0.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  38.83
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  arteannuin B 反应 2.5h， 生成 青蒿素
  参考文献：
  名称：

  Enzymatic Synthesis of Artemisinin from Natural and Synthetic Precursors

  摘要：

  To investigate the biosynthetic pathway of artemisinin, an assay system for the determination of activity of the enzymes involved in its synthesis has been developed. Results from these experiments have; shown that HEPES provides a better buffer system than Tris-HCl. The enzyme(s) requires Mg2+ and/or Mn2+, and the addition of ATP and NADPH+H+ significantly enhances the enzyme activity. A new substrate, dihydroarteannuin B, has been synthesized that can easily be radiolabeled with high specific activity. It is utilized by the enzyme system and is converted to artemisinin with the same efficiency as the natural substrates. This can be conveniently used as a precursor for elucidation of the pathway for artemisinin biosynthesis.

  DOI：

  10.1021/np970024s

文献信息

• Enzymatic Synthesis of Artemisinin from Natural and Synthetic Precursors
  作者：Shalini Bharel、Anamika Gulati、M. Z. Abdin、P. S. Srivastava、R. A. Vishwakarma、S. K. Jain

  DOI：10.1021/np970024s

  日期：1998.5.1

  To investigate the biosynthetic pathway of artemisinin, an assay system for the determination of activity of the enzymes involved in its synthesis has been developed. Results from these experiments have; shown that HEPES provides a better buffer system than Tris-HCl. The enzyme(s) requires Mg2+ and/or Mn2+, and the addition of ATP and NADPH+H+ significantly enhances the enzyme activity. A new substrate, dihydroarteannuin B, has been synthesized that can easily be radiolabeled with high specific activity. It is utilized by the enzyme system and is converted to artemisinin with the same efficiency as the natural substrates. This can be conveniently used as a precursor for elucidation of the pathway for artemisinin biosynthesis.