tris(triphenylphosphine)ruthenium(II) chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tris(triphenylphosphine)ruthenium(II) chloride
• 英文别名: dichlorotris(triphenylphospine)ruthenium(II)；RuCl2(PPh3)3；[RuCl2(triphenylphosphine)3]；Cl2Ru(triphenylphosphine)3；RuCl2(triphenylphosphine)3；Ru(PPh3)3Cl2；Ruthenium(2+);triphenylphosphane;chloride
• 化学式: 3C₁₈H₁₅P*2Cl*Ru
• 分子量: 958.849
• InChiKey: ZSNSPTRSMWAKDE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.45
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tris(triphenylphosphine)ruthenium(II) chloride 在 catalyst: 2-pyridyl methyl ketone 作用下， 以 氯仿 为溶剂， 以92%的产率得到dichlororuthenium;triphenylphosphane
  参考文献：
  名称：

  Characterization of soluble [RuCl2P2]2 (P = PPh3), a species which has been postulated to be present in solutions of RuCl2P3; its synthesis from various Ru compounds via a novel catalytic process involving pyridylketones

  摘要：

  DOI：

  10.1016/s0020-1693(00)87165-0
• 作为产物：
  描述：

  methanol;trichlororuthenium;triphenylphosphane 在 氢气 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 生成 tris(triphenylphosphine)ruthenium(II) chloride
  参考文献：
  名称：

  On the existence of dioxygen adducts of ruthenium (II) tertiary-arsine and -phosphine complexes

  摘要：

  DOI：

  10.1016/s0020-1693(00)94065-9
• 作为试剂：
  描述：

  去甲伪麻黄碱 在 4-二甲氨基吡啶 、 正丁基锂 、 tris(triphenylphosphine)ruthenium(II) chloride 、 C₆H₁₃BH₂ (from borane-tetrahydrofuran and 2,3-dimethylbut-2-ene) 、 双氧水 、 草酸 、 碳酸氢钠 、 potassium carbonate 、 N-甲基吗啉氧化物 、 N,N-二异丙基乙胺 、 silver carbonate 、 9-硼杂双环[3.3.1]壬基三氟甲磺酸酯 作用下， 以 甲醇 、 二氯甲烷 、 丙酮 、 甲苯 为溶剂， 反应 41.5h， 生成 (2'R,2''S,3''S,4R,5S,5''R)-(+)-<2'-(3'',5''-dimethyl-6''-oxotetrahydropyran-2''-yl)-1'-oxobutyl>-4-methyl-5-phenyloxazolidin-2-one
  参考文献：
  名称：

  Brimble, Margaret A., Australian Journal of Chemistry, 1990, vol. 43, # 6, p. 1035 - 1046

  摘要：

  DOI：

文献信息

• (4-alkoxypyran-4-yl) substituted arylalkylaryl-, aryalkenylaryl-, and
  申请人：Abbott Laboratories

  公开号：US05432194A1

  公开（公告）日：1995-07-11

  Compounds of the structure ##STR1## wherein W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.6 and R.sup.7 are hydrogen or alkyl, or R.sup.6 and R.sup.7, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## R.sup.8 is selected from hydrogen, alkyl, haloalkyl, optionally substituted phenyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, (alkoxycarbonyl)alkyl, and (alkylaminocarbonyl)alkyl; Z is --CH.sub.2 --, oxygen, sulfur, or --NR.sup.9 where R.sup.9 is hydrogen or alkyl, L.sup.1 and L.sup.2 are selected from a valence bond, alkylene, propenylene, and propynylene, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from alkyl, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is selected from oxygen, --NR.sup.10, where R.sup.10 is hydrogen or alkyl, and ##STR4## where n=0, 1, or 2, and R.sup.5 is alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

  结构为##STR1##的化合物，其中W从##STR2##中选择，其中Q为氧或硫，R.sup.6和R.sup.7为氢或烷基，或者R.sup.6和R.sup.7与它们连接的氮原子一起定义为##STR3##的基团，R.sup.8从氢、烷基、卤代烷基、可选择取代的苯基、羟基烷基、氨基烷基、羧基烷基、(烷氧羰基)烷基和(烷基氨基羰基)烷基中选择；Z为--CH.sub.2 --、氧、硫或--NR.sup.9，其中R.sup.9为氢或烷基，L.sup.1和L.sup.2从价键、烷基、丙烯基和丙炔基中选择，R.sup.1、R.sup.2、R.sup.3和R.sup.4分别从烷基、卤代烷基、卤素、氰基、氨基、烷氧羰基和二烷基氨基羰基中独立选择，Y从氧、--NR.sup.10中选择，其中R.sup.10为氢或烷基，以及##STR4##其中n=0、1或2，R.sup.5为烷基，抑制白三烯的生物合成。这些化合物在治疗或缓解过敏和炎症性疾病状态中很有用。
• Process for making 2,3-dihalopropanols
  申请人：The Dow Chemical Company

  公开号：US06008419A1

  公开（公告）日：1999-12-28

  A 2,3-dihalopropanol is made by reacting 2,3-dihalopropanal with molecular hydrogen in the presence of a transition metal-containing catalyst, under conditions such that 2,3-dihalopropanol is formed. The reaction is particularly useful, for example, as Step (3) in a process to make epihalohydrin which may be generally prepared by: (1) reacting a 3-carbon hydrocarbon with an oxidizing agent to form acrolein; (2) reacting acrolein with a molecular halogen to form 2,3-dihalopropanal; (3) reducing 2,3-dihalopropanal with molecular hydrogen to form 2,3-dihalopropanol; and (4) cyclizing 2,3-dihalopropanol to make epihalohydrin. The process produces epihalohydrin using only about one mole of halogen per mole of epihalohydrin. It also uses substantially less water than existing processes.

  2,3-二卤代丙醇是通过在含有过渡金属催化剂的条件下，将2,3-二卤代丙醛与分子氢反应制得的。该反应特别有用，例如，作为制备环氧卤代环氧丙烷的过程中的第三步，该过程通常可通过以下步骤制备：(1)将3碳烃与氧化剂反应以形成丙烯醛；(2)将丙烯醛与分子卤素反应以形成2,3-二卤代丙醛；(3)将2,3-二卤代丙醛与分子氢还原以形成2,3-二卤代丙醇；(4)将2,3-二卤代丙醇环化以制备环氧卤代环氧丙烷。该过程每摩尔环氧卤代环氧丙烷仅使用约一摩尔卤素。它还比现有工艺使用的水量大大减少。
• Process to make 2,3-dihalopropanols
  申请人：The Dow Chemical Company

  公开号：US05744655A1

  公开（公告）日：1998-04-28

  A 2,3-dihalopropanol is made by reacting 2,3-dihalopropanal with a hydrogenating agent in the presence of a transition metal-containing catalyst, under conditions such that 2,3-dihalopropanol is formed. The reaction is particularly useful as Step (3) in a process to make epihalohydrin by: (1) reacting a 3-carbon hydrocarbon with an oxidizing agent to form acrolein; (2) reacting acrolein with a molecular halogen to form 2,3-dihalopropanal; (3) reducing 2,3-dihalopropanal to form 2,3-dihalopropanol; and (4) cyclizing 2,3-dihalopropanol to make epihalohydrin. The process produces epihalohydrin using only about one mole of halogen per mole of epihalohydrin. It also uses substantially less water than existing processes.

  一种2,3-二卤代丙醇是通过在含有过渡金属催化剂的条件下，将2,3-二卤代丙醛与氢化剂反应制得的。该反应在制备环氧卤代环氧丙烷的过程中特别有用，包括：(1)将3碳烃与氧化剂反应制得丙烯醛；(2)将丙烯醛与分子卤素反应制得2,3-二卤代丙醛；(3)还原2,3-二卤代丙醛制得2,3-二卤代丙醇；(4)将2,3-二卤代丙醇环化制得环氧卤代环氧丙烷。该过程每摩尔环氧卤代环氧丙烷仅使用约一摩尔卤素。同时，该过程使用的水量明显少于现有工艺。
• Quinolone-and naphthyridonecarboxylic acid derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US05605910A1

  公开（公告）日：1997-02-25

  The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a tricyclic amine radical, their salts, processes for their preparation and antibacterial compositions comprising these compounds.

  该发明涉及一种新的喹诺酮和萘喹啉酮羧酸衍生物，其在7位被三环胺基取代，以及它们的盐、制备方法和包括这些化合物的抗菌组合物。
• Cyclic amidino agents useful as nitric oxide synthase inhibitors
  申请人：G.D. Searle & Co.

  公开号：US06011028A1

  公开（公告）日：2000-01-04

  The current invention discloses useful amidino derivative useful as nitric oxide synthase inhibitors.

  当前的发明揭示了作为一氧化氮合酶抑制剂有用的胍基衍生物。