gypensapogenin R

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: gypensapogenin R
• 化学式: C₄₂H₇₂O₁₃
• 分子量: 785.026
• InChiKey: NILJSZGSXGTJKL-LUQCTAAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.15
• 重原子数：
  55.0
• 可旋转键数：
  11.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  218.99
• 氢给体数：
  9.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  gypensapogenin R 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 葡萄糖
  参考文献：
  名称：

  Protective effects of dammarane-type triterpenes from hydrolyzate of Gynostemma pentaphyllum against H 2 O 2 -induced injury and anti-hepatic fibrosis activities

  摘要：

  Gynostemma pentaphyllum (Thunb.) Makino is a kind of health food, and it is also used as a traditional medicine in Asia. In this study, phytochemical investigation of hydrolyzate of total G. pentaphyllum saponins led to the isolation of three previously undescribed triterpenes, Gypensapogenin R(1), Gypensapogenin S(2), and Gypensapogenin T(3). Their structures were mainly identified by 1D, 2D-NMR and HR-ESI-MS evidences. Antihepatic fibrosis activity was determined and the data showed that 2 and 3 exhibited more potent inhibitory effects (IC50 values 14.93 and 29.19, respectively) on the growth of t-HSC/Cl-6 cells than Silymarin (positive control), while having much weaker effect in the growth of normal cell. Additionally, all the compounds exhibited excellent increased the ratio of viability of H9c2 induced by H2O2. Here in we report isolation, structure elucidation, as well as the evaluation of the anti-hepatic fibrosis and cardiomyocytes oxidative injury activities of these three compounds.

  DOI：

  10.1016/j.phytol.2018.03.010

文献信息

• Protective effects of dammarane-type triterpenes from hydrolyzate of Gynostemma pentaphyllum against H 2 O 2 -induced injury and anti-hepatic fibrosis activities
  作者：Xiaoshu Zhang、Guohui Shi、Mingbing Liu、Rong Chen、Xiaojun Wu、Yuqing Zhao

  DOI：10.1016/j.phytol.2018.03.010

  日期：2018.6

  Gynostemma pentaphyllum (Thunb.) Makino is a kind of health food, and it is also used as a traditional medicine in Asia. In this study, phytochemical investigation of hydrolyzate of total G. pentaphyllum saponins led to the isolation of three previously undescribed triterpenes, Gypensapogenin R(1), Gypensapogenin S(2), and Gypensapogenin T(3). Their structures were mainly identified by 1D, 2D-NMR and HR-ESI-MS evidences. Antihepatic fibrosis activity was determined and the data showed that 2 and 3 exhibited more potent inhibitory effects (IC50 values 14.93 and 29.19, respectively) on the growth of t-HSC/Cl-6 cells than Silymarin (positive control), while having much weaker effect in the growth of normal cell. Additionally, all the compounds exhibited excellent increased the ratio of viability of H9c2 induced by H2O2. Here in we report isolation, structure elucidation, as well as the evaluation of the anti-hepatic fibrosis and cardiomyocytes oxidative injury activities of these three compounds.