8-bromoguanosine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8-bromoguanosine
• 英文别名: 8-bromo-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-imino-5H-purin-6-one
• 化学式: C₁₀H₁₂BrN₅O₅
• 分子量: 362.14
• InChiKey: FKGIRENFNLSWQM-ABEFGGPWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  153
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  8-bromoguanosine 、 炔雌醇 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and biological activities of nucleoside–estradiol conjugates

  摘要：

  Nucleosides were coupled to estradiol via a 17 alpha-ethynyl spacer group using Pd(11) as a catalyst. The conjugates were evaluated in vitro for estrogen receptor (ER) binding affinity and cytotoxicity against cell lines with and without ER. The highest receptor binding affinities (RBA similar or equal to 3) were observed with conjugates coupled via a relative long spacer group, while none of the conjugates exhibited cytotoxicity against either cell lines. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.10.004

文献信息

• Synthesis and biological activities of nucleoside–estradiol conjugates
  作者：Hasrat Ali、Naseem Ahmed、Guillaume Tessier、Johan E. van Lier

  DOI：10.1016/j.bmcl.2005.10.004

  日期：2006.1

  Nucleosides were coupled to estradiol via a 17 alpha-ethynyl spacer group using Pd(11) as a catalyst. The conjugates were evaluated in vitro for estrogen receptor (ER) binding affinity and cytotoxicity against cell lines with and without ER. The highest receptor binding affinities (RBA similar or equal to 3) were observed with conjugates coupled via a relative long spacer group, while none of the conjugates exhibited cytotoxicity against either cell lines. (c) 2005 Elsevier Ltd. All rights reserved.