1-butyl-2,3-diphenyl-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-butyl-2,3-diphenyl-1H-indole
• 英文别名: 1-Butyl-2,3-diphenylindole
• 化学式: C₂₄H₂₃N
• 分子量: 325.453
• InChiKey: DUDFOHUWGPZGGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  3-苯基-1H-吲哚 在 palladium diacetate 、 sodium carbonate 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 N,N-二甲基乙酰胺 、 氯苯 为溶剂， 反应 48.0h， 生成 1-butyl-2,3-diphenyl-1H-indole
  参考文献：
  名称：

  Synthesis of topologically constrained naphthalimide appended palladium(ii)–N-heterocyclic carbene complexes – insights into additive controlled product selectivity

  摘要：

  Pd（ii）-NHC催化的选择性杂环化合物合成方法已被证明，该方法将o-卤代苯胺和芳基乙炔基三甲基硅烷进行杂环化反应，产生吲哚，并且可以通过添加剂来控制可切换的产物选择性。

  DOI：

  10.1039/c8ob00616d

文献信息

• Divergent C–H activation synthesis of chalcones, quinolones and indoles
  作者：Yuesen Shi、Huimin Xing、Tianle Huang、Xuexin Liu、Jian Chen、Xiaoyu Guo、Guo-Bo Li、Yong Wu

  DOI：10.1039/c9cc08926h

  日期：——

  report a condition-controlled divergent synthesis strategy of chalcones, quinolones and indoles, which was achieved via a C-H activation reaction of N-nitrosoanilines and cyclopropenones. Variations of Ag salts are observed to be crucial for divergently constructing the three distinct chemical scaffolds. A Rh(i)- and Rh(iii)-cocatalyzed decarbonylation/C-H activation/[3+2] annulation cascade reaction

  我们在这里报告了一个条件控制的查耳酮，喹诺酮和吲哚的发散合成策略，这是通过N-亚硝基苯胺和环丙烯酮的CH活化反应实现的。观察到Ag盐的变化对于差异化构建三个不同的化学支架至关重要。开发了Rh（i）和Rh（iii）共同催化的脱羰/ CH活化/ [3 + 2]环空级联反应，用于合成吲哚。这些方法的特点是反应条件温和，官能团耐受性高以及对克级合成的适应性，为将来通过CH活化衍生新化学支架提供了参考。
• Rh(<scp>iii</scp>)-catalyzed chemoselective C–H functionalizations of tertiary aniline N-oxides with alkynes
  作者：Xiaolei Huang、Wenbo Liang、Yang Shi、Jingsong You

  DOI：10.1039/c6cc02217k

  日期：——

  Two novel Rh(iii)-catalyzed chemoselective functionalizations of tertiary aniline N-oxides with alkynes, including annulation via the sequential C(sp²)–H and C(sp³)–N activation and an O-atom transfer (OAT) process, have been described.

  两种新颖的Rh(iii)催化的三级苯胺N-氧化物与炔烃的化学选择性官能化反应已被描述，包括通过顺序C(sp²)–H和C(sp³)–N活化以及一个O原子转移（OAT）过程进行环化。
• A Fast Track to Indoles and Annulated Indoles through <i>ortho</i>- vs <i>ipso-</i>Amination of Aryl Halides
  作者：Farnaz Jafarpour、Mehran Ghasemi、Farid Mohaghegh、Sara Asgari、Azizollah Habibi

  DOI：10.1021/acs.orglett.9b04202

  日期：2019.12.20

  halides using non-electrophilic amine sources for construction of indole scaffolds is reported. A palladium-catalyzed alkyne insertion/C-H activation/palladacycle amination via merger of three easily diversified components including iodoarenes, alkynes, and amines delivers indoles with different substitution patterns even in gram scales. By employing ortho-bromoanilines, a consecutive annulative π-extension

  报道了使用非亲电子胺源对吲哚支架进行芳基卤化物的互补位点选择性邻位或异丙位胺化。钯催化的炔烃插入/ CH活化/钯环化胺化反应是通过将三种易于多样化的组分（包括碘代芳烃，炔烃和胺）合并而实现的，即使以克为单位，其吲哚也具有不同的取代方式。通过使用邻溴苯胺，吲哚的连续环式π-延伸通过一锅中的四个CC和CN键形成进行吲哚[1,2-f]菲啶骨架的构建。
• Assembly of Indole Cores through a Palladium-Catalyzed Metathesis of Ar–X σ-Bonds
  作者：Farnaz Jafarpour、Mehran Ghasemi、Hamed Navid、Niloofar Safaie、Saideh Rajai-Daryasarei、Azizollah Habibi、Robert C. Ferrier

  DOI：10.1021/acs.orglett.0c03611

  日期：2020.12.18

  We describe the development of a new method for construction of highly substituted indole scaffolds through the strategic utilizing of the metathesis of Ar-X σ-bonds based on the dynamic nature of palladium-based oxidative addition/reductive elimination. A suitable and simple catalytic system has provided an appropriate platform for a productive ligand exchange and consecutive carbopalladation/C–H

  我们通过基于钯基氧化加/还原消除动力学性质的Ar-Xσ键复分解的战略利用，描述了一种新的构建高度取代的吲哚支架的方法的开发。合适而简单的催化体系为生产有效的配体交换以及连续的碳炔/ C-H活化/膦配体与炔烃和芳族/脂肪族胺的胺化提供了合适的平台，以构建结构多样的吲哚。
• PHOTOSENSITIVE RESIN COMPOSITION
  申请人：CLARIANT INTERNATIONAL LTD.

  公开号：EP1087260A1

  公开（公告）日：2001-03-28

  A radiation sensitive resin composition which contains a specific amount of a fluorescent material and has high sensitivity, high resolution, excellent highly normalized film remaining characteristics , and capability to form a good pattern. In the case that the radiation sensitive resin composition comprises at least both a resin and a photosensitive material, such as an alkali-soluble novolak resin and a quinonediazide compound, the fluorescent material is used in an amount of 0.0001 to 1.0 parts by weight relative to 100 parts by weight of the photosensitive material. In the case that the radiation sensitive resin composition comprises at least both a resin and a photoacid generator, such as a positive-working or negative-working chemically amplified resist, the fluorescent material is used in an amount of 1.0 to 30.0 parts by weight relative to 100 parts by weight of the photoacid generator. The fluorescent material to be used is an organic fluorescent material such as a naphthalene, an anthracene, a phenanthrene, a pyrene, a perylene, a fluorene, a carbazole, a biphenyl, a p-terphenyl, a p-quaterphenyl, an indole, an acridine, a naphthacene, a rublene, a chrysene, or the like.

  一种辐射敏感树脂组合物，它含有一定量的荧光材料，具有高灵敏度、高分辨率、优异的高度归一化胶片剩余特性以及形成良好图案的能力。在辐射敏感树脂组合物至少包含树脂和感光材料（如碱溶性酚醛树脂和喹诺酮噻嗪化合物）的情况下，相对于 100 份感光材料，荧光材料的使用量为 0.0001 至 1.0 份（重量比）。如果辐射敏感树脂组合物至少包括树脂和光酸发生器，例如正向工作或负向工作的化 学放大抗蚀剂，则荧光材料的使用量为 1.0 至 30.0 份（按重量计），相对于 100 份（按 重量计）的光酸发生器。使用的荧光材料为有机荧光材料，如萘、蒽、菲、芘、过烯、芴、咔唑、联苯、对三联苯、对四联苯、吲哚、吖啶、萘、红萘、菊烯等。