clopidogrel camphorsulfate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: clopidogrel camphorsulfate
• 英文别名: (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid;sulfuric acid;1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
• 化学式: C₁₀H₁₆O*C₁₅H₁₄ClNO₂S*H₂O₄S
• 分子量: 558.117
• InChiKey: SLOOFMMAJMDMOC-UTLKBRERSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.33
• 重原子数：
  36
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  169
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• [EN] A NOVEL PROCESS FOR THE MANUFACTURE OF (+)-(S)-CLOPIDOGREL BISULFATE FORM-I<br/>[FR] PROCEDE NOUVEAU DE PREPARATION DE BISULFATE DE (+)-(S)-CLOPIDOGREL DE FORME I
  申请人：WOCKHARDT LTD

  公开号：WO2005012300A1

  公开（公告）日：2005-02-10

  The present invention relates to a novel process for the manufacture of blood-platelet aggregation inhibiting agent. In particular, the present invention is directed to a process for the manufacture of Methyl-(+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-S-(4H)acetate bisulfate Form-I.

  本发明涉及一种制备血小板聚集抑制剂的新工艺。具体而言，本发明涉及一种制备甲基-(+)-(S)-α-(2-氯苯基)-6,7-二氢噻吩[3,2-c]吡啶-S-(4H)醋酸酯双硫酸盐I型的工艺。
• [EN] PROCESSES FOR THE PREPARATION OF CLOPIDOGREL HYDROGEN SULFATE POLYMORPHIC FORM I<br/>[FR] PROCEDES POUR LA PREPARATION DE CLOPIDOGREL HYDROGENOSULFATE DE FORME POLYMORPHE I
  申请人：KRKA TOVARNA ZDRAVIL D D NOVO

  公开号：WO2005100364A1

  公开（公告）日：2005-10-27

  Processes for the preparation of clopidogrel hydrogen sulfate of polymorphic form I are described which include use of specific solvents and process measures to avoid formation of undesired by-products.

  描述了制备多形态I型氢硫酸氯吡格雷的工艺过程，其中包括使用特定溶剂和工艺措施以避免产生不良副产物。
• Novel process for the manufacture of (+)-(s)-clopidogrel bisulfate form-1
  申请人：Mukarram Jaweed Mohammed Siddiqui

  公开号：US20060183907A1

  公开（公告）日：2006-08-17

  The present invention relates to a novel process for the manufacture of blood-platelet aggregation inhibiting agent. In particular, the present invention is directed to a process for the manufacture of Methyl-(+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-S-(4H)acetate bisulfate Form-I.

  本发明涉及一种新型血小板聚集抑制剂的制造工艺。具体而言，本发明涉及一种用于制造甲基-(+)-(S)-α-(2-氯苯基)-6,7-二氢噻吩[3,2-c]吡啶-S-(4H)乙酸盐双硫酸盐I型的工艺。
• Processes For The Preparation Of Clopidogrel Hydrogen Sulfate Polymorphic Form I
  申请人：Mao Haifang

  公开号：US20090234123A1

  公开（公告）日：2009-09-17

  Processes for the preparation of clopidogrel hydrogen sulfate of polymorphic form I are described which include use of specific solvents and process measures to avoid formation of undesired by-products.

  本文描述了制备多晶形式I的氢硫酸氯吡格雷的过程，包括使用特定的溶剂和工艺措施以避免形成不良副产物。
• Novel process for the manufacture of (+)-(S)-clopidogrel bisulfate form-1
  申请人：Mukarram Siddiqui Jaweed Mohammed

  公开号：US20080051581A1

  公开（公告）日：2008-02-28

  The present invention relates to a novel process for the manufacture of blood-platelet aggregation inhibiting agent. In particular, the present invention is directed to a process for the manufacture of Methyl-(+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-S-(4H)acetate bisulfate Form-I.

  本发明涉及一种新型制造血小板聚集抑制剂的方法。具体而言，本发明涉及一种制造甲基-(+)-(S)-α-(2-氯苯基)-6,7-二氢噻吩[3,2-c]吡啶-S-(4H)酯双硫酸盐I型的方法。