2-(4-hydroxycyclohexyl)acetonitrile

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-hydroxycyclohexyl)acetonitrile
• 英文别名: trans-(4-hydroxy-cyclohexyl)-acetonitrile；2-[(1r,4r)-4-Hydroxycyclohexyl]acetonitrile
• 化学式: C₈H₁₃NO
• 分子量: 139.197
• InChiKey: CGWCOCZJNUTOHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  44
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-hydroxycyclohexyl)acetonitrile 、 苯甲酸 在 N-甲基咪唑 、 对甲苯磺酰氯 作用下， 以 乙腈 为溶剂， 以88%的产率得到trans-benzoic acid 4-cyanomethyl-cyclohexyl ester
  参考文献：
  名称：

  NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE

  摘要：

  公开号：

  EP2256105B1
• 作为产物：
  描述：

  Acetic acid 4-cyanomethyl-cyclohexyl ester 、 sodium methylate 、 水 以78%的产率得到
  参考文献：
  名称：

  KRIEG, R.;SCHIERHORN, M.;ALTMANN, H.;DEUTSCHER, H. -J., J. PRAKT. CHEM., 329,(1987) N 6, 1123-1130

  摘要：

  DOI：

文献信息

• [EN] HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS<br/>[FR] MODULATEURS ALLOSTÉRIQUES DES PROTÉINES DU NOYAU DE L'HÉPATITE B
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2015138895A1

  公开（公告）日：2015-09-17

  ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

  摘要 本公开提供了部分具有对乙型肝炎病毒Cp具有变构效应的化合物。本文还提供了治疗病毒感染（如乙型肝炎）的方法，包括向需要的患者施用所述化合物。
• TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS
  申请人：Incyte Corporation

  公开号：US20140121198A1

  公开（公告）日：2014-05-01

  The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

  本发明提供了三环融合噻吩衍生物，以及它们的组合物和使用方法，这些衍生物调节Janus激酶（JAK）的活性，并且在治疗与JAK活性相关的疾病方面具有用处，例如炎症性疾病、自身免疫性疾病、癌症和其他疾病。
• MULTIFUNCTIONAL DEOXYBENZOIN-BASED MONOMERS AND RESINS HAVING REDUCED FLAMMABILITY
  申请人：University of Massachusetts

  公开号：US20140357829A1

  公开（公告）日：2014-12-04

  The invention provides a novel platform for minimal- or non-flammable polymers, which is based purely on hydrocarbon systems and does not need additives of any kind A key feature is that the hydrocarbons disclosed herein are characterized by degradation mechanisms that produce few flammable volatiles. For example, 2,4,4′,6-tetrahydroxydeoxybenzoin is employed as a multifunctional cross-linker in conjunction with bis-epoxydeoxybenzoin, affording new resins that combine excellent physical and mechanical properties with low flammability.

  本发明提供了一种基于纯烃系统的新型最小或非易燃聚合物平台，不需要任何添加剂。其关键特点是所披露的烃类具有产生少量易燃挥发物的降解机制。例如，2,4,4′,6-四羟基脱氧苯并酚可与双环氧脱氧苯并酚共同作为多功能交联剂，形成新的树脂，将优异的物理和机械性能与低易燃性相结合。
• Liquid Crystal Compound Having Lactone Ring, Liquid Crystal Composition, And Liquid Crystal Display Device
  申请人：GOTO Mayumi

  公开号：US20100038588A1

  公开（公告）日：2010-02-18

  A nematic liquid crystal compound represented by any one of formulas (a-1) to (a-6): in formulas (a-1) to (a-6), Ra and Rb are each independently hydrogen or alkyl having 1 to 10 carbons, provided that in the alkyl, —CH2- may be replaced by —O—, —(CH2)2- may be replaced by —CH═CH—, and hydrogen may be replaced by a halogen; ring A1 and ring A2 are each independently trans-1,4-cyclohexylene or 1,4-phenylene, provided that in these rings hydrogen may be replaced by a halogen, and in the case where the ring is trans-1,4-cyclohexylene, —CH2- may be replaced by —O—, and —CH2CH— may be replaced by —CH═C—; and Z1 and Z2 are each independently a single bond, —COO—, —OCO—, —OCH2-, —CH2O— or —CH2CH2-, provided that in formula (a-3), in the case where ring A2 is trans-1,4-cyclohexylene, Z2 is a single bond, —COO—, —OCO—, —OCH2- or —CH2O—, in the case where Ra is —C3H7, Rb is —OC2H5, and Z2 is a single bond, ring A2 is trans-1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 2-fluoro- 1,4 -phenylene, 3-fluoro-1,4-phenylene, 2-fluoro-3-chloro-1,4-phenylene, 2-chloro- 3 -fluoro-3,4-phenylene or 2,3-dichloro-1,4-phenylene, and in formula (a-4), in the case where ring A1 is trans-1,4-cyclohexylene, Z1 is a single bond, —COO—, —OCO—, —OCH2- or —CH2O—.

  任意一种由公式(a-1)到(a-6)中的任意一种表示的向列相液晶化合物:在公式(a-1)到(a-6)中，Ra和Rb分别独立地表示氢或具有1到10个碳的烷基，但在烷基中，—CH2-可以被—O—替换，—(CH2)2-可以被—CH═CH—替换，并且氢可以被卤素替换;环A1和环A2分别独立地表示反式1,4-环己烯基或1,4-苯基，但在这些环中氢可以被卤素替换，在环为反式1,4-环己烯基的情况下，—CH2-可以被—O—替换，—CH2CH—可以被—CH═C—替换;Z1和Z2分别独立地表示单键、—COO—、—OCO—、—OCH2-、—CH2O—或—CH2CH2-，但在公式(a-3)中，在环A2为反式1,4-环己烯基的情况下，Z2为单键、—COO—、—OCO—、—OCH2-或—CH2O—，在Ra为—C3H7，Rb为—OC2H5，Z2为单键，环A2为反式1,4-环己烯基，1,3-二氧杂环戊烷-2,5-二基，2-氟-1,4-苯基，3-氟-1,4-苯基，2-氟-3-氯-1,4-苯基，2,3-二氯-1,4-苯基，在公式(a-4)中，在环A1为反式1,4-环己烯基的情况下，Z1为单键、—COO—、—OCO—、—OCH2-或—CH2O—。
• Hepatitis B core protein allosteric modulators
  申请人：Indiana University Research and Technology Corporation

  公开号：US10183936B2

  公开（公告）日：2019-01-22

  The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

  本公开内容部分提供了对乙型肝炎病毒 Cp 具有异生效应特性的化合物。本文还提供了治疗病毒感染（如乙型肝炎）的方法，包括向有需要的患者施用所公开的化合物。