3-O-β-L-fucopyranosyl-23,28-dihydroxy-11-methoxy-12-oleanane

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-O-β-L-fucopyranosyl-23,28-dihydroxy-11-methoxy-12-oleanane
• 英文别名: mimengoside H；(2R,3S,4R,5S,6S)-2-[[(3S,4R,4aR,6aR,6bS,8aS,12aS,14R,14aR,14bS)-4,8a-bis(hydroxymethyl)-14-methoxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-6-methyloxane-3,4,5-triol
• 化学式: C₃₇H₆₂O₈
• 分子量: 634.894
• InChiKey: CHVWLPSPCORJBL-XVGBUFJCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  45
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  129
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  3-O-β-L-fucopyranosyl-23,28-dihydroxy-11-methoxy-12-oleanane 在 盐酸 作用下， 以 水 为溶剂， 反应 4.0h， 生成 L(-)岩藻糖
  参考文献：
  名称：

  Two new compounds from the fruits ofBuddleja lindleyanawith neuroprotective effect

  摘要：

  Two new triterpenoid glycosides, mimengosides H (1) and I (2), were isolated from the fruits of Buddleja lindleyana Fort. Their structures were determined by extensive spectroscopic methods. Neuroprotective effects of these isolates against 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells were evaluated. Pretreatment with compound 1 had potential protective effect in a concentration range from 0.1 to 1 mu mol l(-1).

  DOI：

  10.1080/10286020.2011.653783

文献信息

• Two new compounds from the fruits of<i>Buddleja lindleyana</i>with neuroprotective effect
  作者：De-Ling Wu、Yang-Kui Wang、Jing-Song Liu、Xun-Cui Wang、Wei Zhang

  DOI：10.1080/10286020.2011.653783

  日期：2012.4

  Two new triterpenoid glycosides, mimengosides H (1) and I (2), were isolated from the fruits of Buddleja lindleyana Fort. Their structures were determined by extensive spectroscopic methods. Neuroprotective effects of these isolates against 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells were evaluated. Pretreatment with compound 1 had potential protective effect in a concentration range from 0.1 to 1 mu mol l(-1).