(±)-pinoresinol

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 呋喃类木脂素
• 英文名称: (±)-pinoresinol
• 英文别名: 4-[(3S,6S)-6-(4-hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol
• 化学式: C₂₀H₂₂O₆
• 分子量: 358.391
• InChiKey: HGXBRUKMWQGOIE-XGMIPLPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  松柏醇 在 β-cyclodextrin 、 fungal laccase LAC₃ from Trametes sp. C₃₀ 作用下， 以 aq. buffer 为溶剂， 反应 8.0h， 生成 (±)-pinoresinol 、 guaiacylglycerol 8-O-4’-coniferyl alcohol ether 、 (±)-dehydrodiconiferyl alcohol
  参考文献：
  名称：

  控制松柏醇与环糊精的聚合†

  摘要：

  松柏醇的单电子氧化导致苯氧基的形成，并最终导致二聚木脂素和新木脂素产物的合成。松柏醇和二聚体产物都是环糊精（CD）形成非共价宿主-客体包涵体复合物的潜在客体。在本文中，研究了具有不同空腔体积的CD（即α，β或CD）对漆酶驱动的松柏醇氧化的影响。我们清楚地表明，βCD与二聚体产物相互作用，并选择性地阻止其进一步被酶氧化。此外，在生成的三种二聚体产物中，含有漆酶和βCD的体系可选择性富集松脂醇；这种行为类似于植物的稀疏蛋白。

  DOI：

  10.1039/c8nj01039k

文献信息

• METHOD FOR MINIMIZING THE CYTOTOXICITY OF THE EFFECTIVE AGENT IN A COMPOSITION THAT IS ADMINISTERED TO A MAMMAL OR GETS INTO CONTACT WITH A MAMMAL
  申请人：Oy Granula AB LTD

  公开号：EP2252154B1

  公开（公告）日：2016-01-27
• METHOD FOR MINIMIZING THE CYTOTOXICITY OF THE EFFECTIVE AGENT INHIBITING THE GROWTH OF MICRO-ORGANISMS AND FOR MAXIMIZING THE EFFECT
  申请人：Oy Granula AB LTD

  公开号：EP2252155B1

  公开（公告）日：2016-01-27
• METHOD FOR PREPARING A COMPOSITION COMPRISING A COMPOUND MIXTURE AND A CARRIER AGENT
  申请人：AHLNAS Thomas

  公开号：US20100129304A1

  公开（公告）日：2010-05-27

  In a method for preparing a composition including a compound mixture and a carrier agent, the compound mixture is obtained by pulverizing the wood material and/or by extracting the wood material so that the compound mixture contains at least two different compounds, selected from a first specified group, at least one compound selected from a second specified group, the compound mixture is mixed with the carrier agent, the amount of the compound mixture is kept in a range of 0.1-5 wt % from the total weight of the composition, providing that the range is also such that the total cytotoxicity of compound mixture dissolved in ethanol, measured for a HaCat cell culture after 24 h incubation period, is lower than the cytotoxicity of 0.02-0.1 wt % butylated hydroxy toluene (BHT) dissolved in ethanol for a HaCat cell culture after 24 h incubation period.
• US8496974B2
  申请人：——

  公开号：US8496974B2

  公开（公告）日：2013-07-30
• [EN] METHOD FOR MINIMIZING THE CYTOTOXICITY OF THE EFFECTIVE AGENT INHIBITING THE GROWTH OF MICRO-ORGANISMS AND FOR MAXIMIZING THE EFFECT<br/>[FR] PROCÉDÉ POUR RÉDUIRE LA CYTOTOXICITÉ DE L'AGENT ACTIF INHIBANT LA CROISSANCE DE MICRO-ORGANISMES ET POUR AUGMENTER SON EFFET
  申请人：OY GRANULA AB LTD

  公开号：WO2009101262A2

  公开（公告）日：2009-08-20

  The invention relates to a mixture to be included in a composition or its semi-finished product, which composition or its semi-finished product contains at least one anti-micro-organistic agent; a possible solvent system with either hydrophobic or hydrophilic nature, selected according to the target of usage; as well as possible surface active agent. The mixture is obtained by pulverizing wood or plant material and/or by extracting the possibly pulverized wood or plant material, so that said mixture contains at least two different polyphenolic compounds selected from the following group: lignans, stilbenes, juvabiones and flavonoids; said mixture further containing oligomers of said polyphenolic compounds, so that the mixture also must have the following properties: the mixture has an anti-micro-organistic effect in the composition or in the semi-finished product; the cytotoxicity of the polyphenols contained in the mixture is at least 10 times lower with respect to BHT; the mixture does not irritate the skin in a so-called single patch test with contents of 0.1 wt%.