2-((methylthio)methyl)quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-((methylthio)methyl)quinoline
• 英文别名: 2-(Methylsulfanylmethyl)quinoline
• 化学式: C₁₁H₁₁NS
• 分子量: 189.281
• InChiKey: QPGWRKFQAOTMLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  喹啉 、 二甲基硫 在 二叔丁基过氧化物 、 yttrium(III) trifluoromethanesulfonate 作用下， 反应 24.0h， 以38%的产率得到2-((methylthio)methyl)quinoline
  参考文献：
  名称：

  Rare-Earth Y(OTf)₃ Catalyzed Coupling Reaction of Ethers with Azaarenes

  摘要：

  Rare-earth catalysis has become a hot topic in the field of catalytic organic reaction. Chain ethers mostly have lower reactivity and lower boiling points which limited their reaction scope. Herein, we found a rare-earth Y(OTf)(3) can catalyze the coupling reaction of ethers especially chain ethers and thioethers with azaarenes. This protocol features simple operations, a broad substrate scope (31 examples), moderate to good yields (up to 85%), and atom economy.

  DOI：

  10.1021/acs.orglett.9b02763

文献信息

• DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20210292300A1

  公开（公告）日：2021-09-23

  Disclosed are compounds of Formula (I) or a salt thereof, wherein R 1 ; R 3 , R 4 , R 5 , m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
• Rare-Earth Y(OTf)₃ Catalyzed Coupling Reaction of Ethers with Azaarenes
  作者：Yue-Hua Wu、Nai-Xing Wang、Tong Zhang、Lei-Yang Zhang、Xue-Wang Gao、Bao-Cai Xu、Yalan Xing、Jian-Yi Chi

  DOI：10.1021/acs.orglett.9b02763

  日期：2019.9.20

  Rare-earth catalysis has become a hot topic in the field of catalytic organic reaction. Chain ethers mostly have lower reactivity and lower boiling points which limited their reaction scope. Herein, we found a rare-earth Y(OTf)(3) can catalyze the coupling reaction of ethers especially chain ethers and thioethers with azaarenes. This protocol features simple operations, a broad substrate scope (31 examples), moderate to good yields (up to 85%), and atom economy.