4,6-dichloro-3-formyl-2-(2-hydroxyethen-1-yl)quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4,6-dichloro-3-formyl-2-(2-hydroxyethen-1-yl)quinoline
• 英文别名: 4,6-dichloro-2-[(E)-2-hydroxyethenyl]quinoline-3-carbaldehyde
• 化学式: C₁₂H₇Cl₂NO₂
• 分子量: 268.099
• InChiKey: IIHVBMPWNLMOFP-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,6-dichloro-3-formyl-2-(2-hydroxyethen-1-yl)quinoline 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 1.5h， 以63%的产率得到9,11-dichloro-3H-diazepino[5,4-b]quinoline
  参考文献：
  名称：

  Synthesis, antimicrobial activities and cytogenetic studies of newer diazepino quinoline derivatives via Vilsmeier–Haack reaction

  摘要：

  The study of the Vilsmeier-Haack reagent on 4-hydroxyquinaidines resulted in a new versatile intermediate 4-chloro-3-formyl-2-(2-hydroxy-ethene-1-yl)quinolines, which on further treatment with hydrazine hydrate yielded the desired diazepino quinoline derivatives. All the synthesized diazepino quinoline derivatives are screened for their antibacterial and antifungal activities. Cytogenetic analysis of the samples is also reported. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.01.004
• 作为产物：
  描述：

  6-氯-2-甲基-4-羟基喹啉 、 N,N-二甲基甲酰胺 在 三氯氧磷 作用下， 反应 17.5h， 以78%的产率得到4,6-dichloro-3-formyl-2-(2-hydroxyethen-1-yl)quinoline
  参考文献：
  名称：

  Kumar, Nandha; Suresh; Dhanabal, Journal of the Indian Chemical Society, 2004, vol. 81, # 7, p. 598 - 601

  摘要：

  DOI：

文献信息

• Kumar, Nandha; Suresh; Dhanabal, Journal of the Indian Chemical Society, 2004, vol. 81, # 7, p. 598 - 601
  作者：Kumar, Nandha、Suresh、Dhanabal、Mohan

  DOI：——

  日期：——
• Kumar, R. Nandha; Suresh; Dhanabal, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007, vol. 46, # 6, p. 995 - 1000
  作者：Kumar, R. Nandha、Suresh、Dhanabal、Mohan

  DOI：——

  日期：——
• Synthesis, antimicrobial activities and cytogenetic studies of newer diazepino quinoline derivatives via Vilsmeier–Haack reaction
  作者：R. Nandhakumar、T. Suresh、A.L. Calistus Jude、V. Rajesh kannan、P.S. Mohan

  DOI：10.1016/j.ejmech.2007.01.004

  日期：2007.8

  The study of the Vilsmeier-Haack reagent on 4-hydroxyquinaidines resulted in a new versatile intermediate 4-chloro-3-formyl-2-(2-hydroxy-ethene-1-yl)quinolines, which on further treatment with hydrazine hydrate yielded the desired diazepino quinoline derivatives. All the synthesized diazepino quinoline derivatives are screened for their antibacterial and antifungal activities. Cytogenetic analysis of the samples is also reported. (c) 2007 Elsevier Masson SAS. All rights reserved.