Neu5Acα(2-3)Gal | 83563-61-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Neu5Acα(2-3)Gal
• 英文别名: N-Acetylneuraminyl-(2-3)-galactose；(2S,4S,5R,6R)-5-acetamido-4-hydroxy-2-[(2R,3S,4S,5R)-2,4,5,6-tetrahydroxy-1-oxohexan-3-yl]oxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
• CAS: 83563-61-5
• 化学式: C₁₇H₂₉NO₁₄
• 分子量: 471.416
• InChiKey: RYXGNICFFBWCJA-LRRROBGASA-N

物化性质

• 沸点：
  990.9±65.0 °C(Predicted)
• 密度：
  1.66±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  264
• 氢给体数：
  10
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  N-乙酰神经氨酸 、 口服葡萄糖 在 Neisseria meningitides CMP-Sia synthetase 、 Pasteurella multocida α2,3-sialyltransferase 、 magnesium 、 胞苷-5’-三磷酸 作用下， 以 aq. buffer 为溶剂， 生成 Neu5Acα(2-3)Gal
  参考文献：
  名称：

  Two-Step Chemoenzymatic Detection of N-Acetylneuraminic Acid−α(2-3)-Galactose Glycans

  摘要：

  Sialic acids are typically linked alpha(2-3) or alpha(2-6) to the galactose that located at the non-reducing terminal end of glycans, playing important but distinct roles in a variety of biological and pathological processes. However, details about their respective roles are still largely unknown due to the lack of an effective analytical technique. Herein, a two-step chemoenzymatic approach for the rapid and sensitive detection of N-acetylneuraminic acid-alpha(2-3)-galactose glycans is described.

  DOI：

  10.1021/jacs.6b07132

文献信息

• Two-Step Chemoenzymatic Detection of <i>N</i>-Acetylneuraminic Acid−α(2-3)-Galactose Glycans
  作者：Liuqing Wen、Yuan Zheng、Kuan Jiang、Mingzhen Zhang、Shukkoor Muhammed Kondengaden、Shanshan Li、Kenneth Huang、Jing Li、Jing Song、Peng George Wang

  DOI：10.1021/jacs.6b07132

  日期：2016.9.14

  Sialic acids are typically linked alpha(2-3) or alpha(2-6) to the galactose that located at the non-reducing terminal end of glycans, playing important but distinct roles in a variety of biological and pathological processes. However, details about their respective roles are still largely unknown due to the lack of an effective analytical technique. Herein, a two-step chemoenzymatic approach for the rapid and sensitive detection of N-acetylneuraminic acid-alpha(2-3)-galactose glycans is described.