4-methoxy-2-methyl-3-(trifluoromethyl)-2H-pyrazolo[4,3-c]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-methoxy-2-methyl-3-(trifluoromethyl)-2H-pyrazolo[4,3-c]quinoline
• 英文别名: 2-Methyl-3-(trifluoromethyl)-4-methoxy-2H-pyrazolo[4,3-c]quinoline；4-methoxy-2-methyl-3-(trifluoromethyl)pyrazolo[4,3-c]quinoline
• 化学式: C₁₃H₁₀F₃N₃O
• 分子量: 281.237
• InChiKey: LMUFUEFOQHHHDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N,N-dimethyl-2-methoxy-3-trifluoroacetyl-4-quinolylamine 、 甲基肼 以 乙腈 为溶剂， 反应 4.0h， 以99%的产率得到4-methoxy-2-methyl-3-(trifluoromethyl)-2H-pyrazolo[4,3-c]quinoline
  参考文献：
  名称：

  Facile Syntheses of Fluorine-Containing 4-Methoxypyrazolo[4,3-c]quinolines and 6-Methoxy-1,4-diazepino[6,5-c]quinolines

  摘要：

  N,N-Dimethy1-2-methoxy-3-trifluoroacety1-4-quinolylamine underwent chemoselective aromatic nucleophilic N-N exchange reaction with hydrazines followed by cyclocondensation to afford the corresponding novel fluorine-containing 4-methoxy-1H-and 2H-pyrazolo[4,3-c]quinolines in good to high yields. Furthermore, the use of 1,2-ethylenediamine and 1,2-phenylenediamines gave the corresponding fluorine-containing 6-methoxy-1,4-diazepino[6,5-c]quinoline derivatives in good yields.

  DOI：

  10.3987/com-16-13420

文献信息

• Facile Syntheses of Fluorine-Containing 4-Methoxypyrazolo[4,3-c]quinolines and 6-Methoxy-1,4-diazepino[6,5-c]quinolines
  作者：Etsuji Okada、Mizuki Hatakenaka、Satoru Adachi

  DOI：10.3987/com-16-13420

  日期：——

  N,N-Dimethy1-2-methoxy-3-trifluoroacety1-4-quinolylamine underwent chemoselective aromatic nucleophilic N-N exchange reaction with hydrazines followed by cyclocondensation to afford the corresponding novel fluorine-containing 4-methoxy-1H-and 2H-pyrazolo[4,3-c]quinolines in good to high yields. Furthermore, the use of 1,2-ethylenediamine and 1,2-phenylenediamines gave the corresponding fluorine-containing 6-methoxy-1,4-diazepino[6,5-c]quinoline derivatives in good yields.