3-(2,4-difluorophenyl)-2-methylacrylic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-(2,4-difluorophenyl)-2-methylacrylic acid
• 英文别名: 2,4-difluoro-α-methylcinnamic acid；(E)-3-(2,4-difluorophenyl)-2-methylprop-2-enoic acid
• 化学式: C₁₀H₈F₂O₂
• 分子量: 198.169
• InChiKey: OXMLWMPAXKIWJK-GQCTYLIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(2,4-difluorophenyl)-2-methylacrylic acid 以 甲醇 为溶剂， 生成 2,4-difluoro-α-methyldihydrocinnamic acid
  参考文献：
  名称：

  Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides

  摘要：

  取代基茚基乙酸和嘧啶并嘧啶衍生物的组合物在结肠息肉的治疗和抑制肿瘤细胞生长方面是有用的。

  公开号：

  US06232312B1
• 作为产物：
  描述：

  2,4-二氟苯甲醛 在 盐酸 、 氢氧化钾 、 sodium proprionate 作用下， 以 水 、 丙酸酐 为溶剂， 生成 3-(2,4-difluorophenyl)-2-methylacrylic acid
  参考文献：
  名称：

  Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides

  摘要：

  取代基茚基乙酸和嘧啶并嘧啶衍生物的组合物在结肠息肉的治疗和抑制肿瘤细胞生长方面是有用的。

  公开号：

  US06232312B1

文献信息

• Esters and amides of substituted indenyl acetic acids
  申请人：FGN, INC.

  公开号：EP0485172A3

  公开（公告）日：1993-01-27

  Esters and amides of substituted indenyl acetic acids of the formula : n is an integer of at least 2 ; Q is a deprotonated residue of polymer or macromolecular structure having a molecular weight of at least about 1000 containing at least two primary and/or secondary amino groups and/or hydroxy groups ;R1 is selected from hydrogen, lower alkyl, or haloalkyl ;R2 is selected from hydrogen or alkyl ;R3 and R4 are one or more members each independently chosen from hydrogen, alkyl, acyloxy, alkoxy, nitro, amino, acylamino, alkylamino, diakylamino, dialkylaminoalkyl, sulfamyl, alkythio, mercapto, hydroxy, hydroxyalkyl, alkylsulfonyl, halogen, cyano, carboxyl, carbalkoxy, carbamido, haloalkyl or cycloalkoxy ; andR5 is selected from alkylsulfenyl, alkylsulfinyl or alkylsulfonyl. are useful in the treatment of colonic polyps.

  取代的茚基乙酸酯和酰胺的化学式为：n是至少为2的整数；Q是具有分子量至少约为1000的聚合物或高分子结构的去质子残基，其中含有至少两个主要和/或次要氨基和/或羟基；R1从氢、较低的烷基或卤代烷基中选择；R2从氢或烷基中选择；R3和R4分别选择自氢、烷基、酰氧基、烷氧基、硝基、氨基、酰胺基、烷基胺基、二烷基胺基、二烷基胺基烷基、磺胺基、烷硫基、巯基、羟基、羟基烷基、烷基磺酰基、卤素、氰基、羧基、羧酰氧基、卤代烷基或环氧基中选择；R5从烷基硫基、烷基亚砜基或烷基砜基中选择。这些化合物在结肠息肉的治疗中很有用。
• Substituted methoxy benzylidene indenyl-acetic and propionic acids for
  申请人：Cell Pathways Inc.

  公开号：US05998477A1

  公开（公告）日：1999-12-07

  Substituted methoxy benzylidene indenyl compounds are useful in the treatment of precancerous lesions and neoplasms.

  甲氧基苄亚甲基吲哚衍生物在治疗癌前病变和肿瘤中是有用的。
• Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives
  申请人：——

  公开号：US20020115885A1

  公开（公告）日：2002-08-22

  Polyhalogenated cinnamic acids and cinnamic acid derivatives are prepared by reacting diazonium salts accessible from polyhalogenated anilines with acrylic acid or acrylic acid derivatives in the presence of a homogeneous, palladium-containing catalyst at about −5 to about +100° C. Some of the cinnamic acids and cinnamic acid derivatives obtainable in this way are new. Cinnamic acids and cinnamic acid derivatives which can be prepared according to the invention can be used for the preparation of indanones which are precursors for agro- and pharmaceutical chemicals and for substances having liquid-crystalline properties.

  聚卤代肉桂酸和肉桂酸衍生物是通过在均相、含钯催化剂存在的条件下，将从多卤代苯胺中可获得的重氮盐与丙烯酸或丙烯酸衍生物反应制备的，反应温度在-5到+100°C左右。通过这种方式获得的一些肉桂酸和肉桂酸衍生物是新的。根据该发明可制备的肉桂酸和肉桂酸衍生物可用于制备印丹酮，印丹酮是农药和药用化学品的前体，也可用于具有液晶性质的物质的制备。
• Method for treating patients with precancerous lesions by administering
  申请人：University of Arizona

  公开号：US05401774A1

  公开（公告）日：1995-03-28

  Substituted indenyl sulfonyl acetic acids are useful in the treatment of precancerous lesions sensitive to treatment with those sulfonyl compounds.

  取代基苯并磺酰乙酸对于对那些磺酰化合物敏感的癌前病变的治疗是有用的。
• Method for treating patients with neoplasia by administering substituted sulfonyl indenyl acetic and propionic acids and esters thereof
  申请人：——

  公开号：US20020107248A1

  公开（公告）日：2002-08-08

  Substituted indenyl sulfonyl acetic acids are useful in the treatment of precancerous lesions.

  取代的茚基磺酰乙酸在治疗癌前病变方面是有用的。