2-{[(benzyloxy) carbonyl] amino} acetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-{[(benzyloxy) carbonyl] amino} acetate
• 英文别名: N-benzyloxycarbonylglycinate；2-(phenylmethoxycarbonylamino)acetate
• 化学式: C₁₀H₁₀NO₄
• 分子量: 208.194
• InChiKey: CJUMAFVKTCBCJK-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  78.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  氢(+1)阳离子 、 水 、 2-{[(benzyloxy) carbonyl] amino} acetate 生成 苯甲醇 、 二氧化碳 、 聚甘氨酸
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  N-苄氧羰基甘氨酸-4-硝基苯酯 在 水 、 四苯基溴化膦 作用下， 以 氯仿 为溶剂， 生成 4-硝基苯酚阴离子 、 2-{[(benzyloxy) carbonyl] amino} acetate
  参考文献：
  名称：

  两相体系氯仿-硼酸盐缓冲液中N-苄氧基羰基甘氨酸4-硝基苯基酯的碱性水解中的相转移催化

  摘要：

  Alkaline hydrolysis of N-benzyloxycarbonylglycine 4-nitrophenyl ester in the two-phase system chloroform-borate buffer (pH 10 and 11) in the presence of C16H33NMe3Br and Ph(4)pZ (Z = Cl, Br, I) at 25 degreesC follows the extraction mechanism where the rate-determining stage is the chemical reaction in the organic phase. The different kinetic profiles of the reaction depending on the nature of Z(-) were explained in terms of concurrent extraction of three kinds of anions: nucleophile OH-, nucleofuge 4-NO2C6H4O-, and foreign ion Z(-) .

  DOI：

  10.1023/a:1012439531879

文献信息

• Nucleic acid triggered catalytic drug and probe release: A new concept for the design of chemotherapeutic and diagnostic agents
  作者：Z Ma

  DOI：10.1016/s0968-0896(01)00245-0

  日期：2001.9

  antiviral and anticancer chemotherapeutic agents that makes use of a disease-specific nucleic acid sequence to template the association of a prodrug with a catalyst which catalyzes the release of the drug. Herein, we report on the effect of mismatches, sterics, and electronics on the rate and specificity of drug and probe release in both two and three component model systems, and on the stability of the

  最近，我们描述了一种设计高度选择性的抗病毒和抗癌化学治疗剂的新概念，该概念利用疾病特异性核酸序列来模板化前药与催化药物释放的催化剂的缔合。本文中，我们报道了错配，空间位阻和电子学对药物和探针释放速率和特异性的影响，包括两个和三个组件模型系统，以及前药接头在人血清中的稳定性。
• ——
  作者：O. V. Baranova、V. V. Kosmynin、V. A. Savelova、A. N. Shendrik、N. I. Korotkikh、G. F. Raenko、A. F. Popov

  DOI：10.1023/a:1016334125761

  日期：——

  Onium salts QZ (Z = Cl, Br) having a lipophilic (Q = R3NR', where R' = C16H33) or readily extractable (into organic phase) cation (Q = Ph4P) exhibit a high catalytic activity in phase-transfer alkaline hydrolysis of N-benzyloxycarbonylglycine 4-nitraphenyl ester in the two-phase system chloroform-borate buffer (pH 10). No catalytic effect is observed in the presence of hydrophilic ammonium salts [Et4NCl, Et3PhCH2NCl, Me-2(NH2)NCH2CH2N(NH2)Me(2)(.)2Br(-)] and those insoluble in organic solvents [(Me)(3)NNH(CH2)(2)COO- (.) 2H(2)O, Me-2(NH2)NCH2CO-, Me-2(NH2)N(CH2)(3)SO3-]. These data suggest extraction mechanism of the process. The activity of lipophilic cation Q is determined mainly by two factors: its extractibility, on the one hand, and the ability to form micelles, on the other.