毒理性
识别：sec-丁胺是一种无色液体，具有氨的气味。它与水和大多数有机溶剂混溶。配方产品包括磷酸盐和碳酸盐。混合溶液在三 天后不稳定，浓缩物或混合溶液需要防止直接光照或极端温度。sec-丁胺是一种杀菌剂，特别有效于控制果实腐烂真菌。 动物研究：将这种化合物作为碳酸盐或醋酸盐给予狗群，并记录心率、呼吸、血压和脑电图仪器的数据。静脉注射醋酸盐或碳酸盐会导致血压、心率和呼吸升高。灌胃大剂量会产生类似反应。使用了20只雄性和20只雌性大鼠进行两窝繁殖，共四代。Fo亲本被允许再生育六个后代。F1b、2b和3b后代被用作下一代的父母，并在断奶后不同时间（162-202天）饲养。繁殖指数、生育指数、妊娠指数、存活指数和哺乳指数均正常。在高饮食水平下，整个研究期间生长减少。Fo一代产生的八个后代繁殖未受影响。将荷兰带兔（每组19只兔）从妊娠第8天到第18天每天给予sec-丁胺。与对照组相比，平均胎儿体重较低，在高剂量水平下存活胎儿数量减少。在繁殖、胎儿性别分布或发现的畸形数量方面，与对照组无差异。将10只雄性和10只雌性大鼠在饮食中给予sec-丁胺醋酸盐3个月。在高剂量水平下，显著生长减少。在雄性和雌性中均记录了剂量相关的白细胞减少。对组织和器官的大体和显微镜检查未发现饮食sec-丁胺的有害影响。将6只雄性和6只雌性家兔在20天内进行皮肤给药。水性溶液中存在表面活性剂。在研究开始前，一半动物的皮肤被磨伤。在研究期间没有死亡，只有磨伤组的一只动物出现不良反应（腹泻）。生长、临床化学、血液学和组织和器官的大体和显微镜检查均正常。根据长期研究，sec-丁胺的致癌潜力被认为是低的。在一项使用牛的饲养研究中，sec-丁胺残留在肌肉、肝脏、脂肪和肾脏中被发现。尿和粪便中的数据显示它容易被吸收到血液中并通过尿液排出。对两只给予sec-丁胺的狗的尿液样本进行酸化和蒸馏。形成一个二苯基肼，这与与甲基乙基酮反应形成的产物相对应。
IDENTIFICATION: sec-Butylamine is a colorless liquid with an ammoniacal odor. It is miscible with water and most organic solvents. Formulated products include phosphate and carbonate salts. Mixed solutions are not stable beyond three days and concentrates or mixed solutions require protection from direct ight or extremes in temperatures. sec-Butylamine is a fungicide particularly effective for the control of fruit rotting fungi. ANIMAL STUDIES: Groups of dogs were administered this compound as the carbonate or acetate salt and data were recorded for heart rate, respiration, blood pressure and EEG apparatus. IV administration of either the acetate or carbonate resulted in elevated blood pressure, heart rate and respiration. Intragastric administration of larger doses resulted in similar responses. Groups of rats 20 males and 20 females were utilized in a two litter generation, four generation. The Fo parents were allowed to bear six additional litters. The F1b, 2b and3b litters were used as parents for the following generation and maintained for varying periods (162-202 days after weaning their respective litters). Reproduction indices, fertility index, sestation index, viability index and lactation index were normal. A reduction of growth was noted throughout the study at the high dietary level. Reproduction was unimpaired for any of the eight litters produced by the Fo generation. Groups of rabbits were fed sec-butylamine phosphate in the diet and subjected to a two generation, one litter per generation reproduction study. Mortality of several animals was evident at the high dose. Animals switched from the high dose to a lower dose had no effect on fertility, duration of gestation, delivery of live progeny or lactation indices in both generations examined. Growth of the progeny in the F1 generation was normal, while it was slightly depressed in the F2. There was no effect of butylamine acetate noted on survival of offspring in either generation. Groups of Dutch Belted does (19 rabbits per group) were administered sec-butylamine daily from Day 8 through 18 of gestation. Mean fetal weights were lower than controls and a decreased viability of live fetuses was noted at the high dose level. There were no differences from controls with respect for reproduction, sex distribution of fetuses or the number of malformations found. Groups of 10 male and 10 female rats were fed sec-butylamine acetate in the diet for 3 months. At the high dose level a significant growth reduction was noted. A dose related leukopenia in both males and females was recorded. Gross and microscopic examination of tissues and organs showed no adverse effects of dietary sec-butylamine. Six male and six female rabbits were treated dermally for 20 days. A surfactant was present in the aqueous solution. The skin of half the animals was abraded prior to the initiation of the study. There was no mortality and only one animal of the abraded group showed adverse reactions (diarrhea) during the study. Growth, clinical chemistry, hematology and gross and microscopic examination of the tissues and organs were normal. The carcinogenic potential of sec-butylamine was judged to be low based on long term studies. In a feeding study using cows, residues of sec-butylamine were found in muscle, liver, fat and kidney. Data on the presence in urine and feces suggest it is easily absorbed in to the blood and excreted in the urine. Urinary samples from two dogs treated with sec-butylamine were acidified and distilled. A diphenylhydrazone was formed which corresponded to the product formed from a reaction with methyl ethyl ketone.[
来源:Hazardous Substances Data Bank (HSDB)
